The Journal of Experimental Medicine
ThymUS '08
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 Mar 19 2007; 204 (3)

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To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.
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IN THIS ISSUE:Back

IN THIS ISSUE [PDF]
Switching defects [Full Text]  
Saving myelin from microglia [Full Text]  
Re-redefining Foxp3 function [Full Text]  
Heavy metal for a troubled heart [Full Text]  
Translated to death [Full Text]  

 

MEETING REPORT:Back

Stay Away From Self: 5th International Congress on Autoimmunity, Sorrento, Italy, November 29–December 3, 2006
Ruth Williams
J. Exp. Med. 2007 204: 456-457. Published online Mar 19 2007, 10.1084/jem.2043mr. [Full Text] [PDF]  

 

FROM THE ARCHIVE:Back

FROM THE ARCHIVE [PDF]
Crossing barriers in transplantation [Abstract] [Full Text]  

 

COMMENTARIES:Back

Oncogenic signaling: new insights and controversies from chronic myeloid leukemia
Richard A. Van Etten
J. Exp. Med. 2007 204: 461-465. Published online Mar 12 2007, 10.1084/jem.20062335. [Abstract] [Full Text] [PDF]  

 

BRIEF DEFINITIVE REPORTS:Back

Smad4 is critical for self-renewal of hematopoietic stem cells
Göran Karlsson, Ulrika Blank, Jennifer L. Moody, Mats Ehinger, Sofie Singbrant, Chu-Xia Deng, and Stefan Karlsson
J. Exp. Med. 2007 204: 467-474. Published online Mar 12 2007, 10.1084/jem.20060465. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Lack of Foxp3 function and expression in the thymic epithelium
Adrian Liston, Andrew G. Farr, Zhibin Chen, Christophe Benoist, Diane Mathis, Nancy R. Manley, and Alexander Y. Rudensky
J. Exp. Med. 2007 204: 475-480. Published online Mar 12 2007, 10.1084/jem.20062465. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung
Jacqueline G. Perrigoue, Ji Li, Colby Zaph, Michael Goldschmidt, Phillip Scott, Frederic J. de Sauvage, Edward J. Pearce, Nico Ghilardi, and David Artis
J. Exp. Med. 2007 204: 481-487. Published online Mar 12 2007, 10.1084/jem.20061791. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo
Tim Worbs, Thorsten R. Mempel, Jasmin Bölter, Ulrich H. von Andrian, and Reinhold Förster
J. Exp. Med. 2007 204: 489-495. Published online Feb 26 2007, 10.1084/jem.20061706. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

 

ARTICLES:Back

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress
César Nombela-Arrieta, Thorsten R. Mempel, Silvia F. Soriano, Irina Mazo, Matthias P. Wymann, Emilio Hirsch, Carlos Martínez-A., Yoshinori Fukui, Ulrich H. von Andrian, and Jens V. Stein
J. Exp. Med. 2007 204: 497-510. Published online Feb 26 2007, 10.1084/jem.20061780. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus
Gundula Min-Oo, Anny Fortin, Giuseppina Pitari, Mifong Tam, Mary M. Stevenson, and Philippe Gros
J. Exp. Med. 2007 204: 511-524. Published online Feb 20 2007, 10.1084/jem.20061252. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes
Judy Tellam, Mark H. Fogg, Michael Rist, Geoff Connolly, David Tscharke, Natasha Webb, Lea Heslop, Fred Wang, and Rajiv Khanna
J. Exp. Med. 2007 204: 525-532. Published online Feb 20 2007, 10.1084/jem.20062508. [Abstract] [Full Text] [PDF]  

MTP regulated by an alternate promoter is essential for NKT cell development
Stephanie K. Dougan, Paul Rava, M. Mahmood Hussain, and Richard S. Blumberg
J. Exp. Med. 2007 204: 533-545. Published online Feb 20 2007, 10.1084/jem.20062006. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R{alpha}–expressing cells
Hans Dooms, Kristen Wolslegel, Patricia Lin, and Abul K. Abbas
J. Exp. Med. 2007 204: 547-557. Published online Feb 20 2007, 10.1084/jem.20062381. [Abstract] [Full Text] [PDF]  

{alpha}Eß7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis
Audrey Le Floc'h, Abdelali Jalil, Isabelle Vergnon, Béatrice Le Maux Chansac, Vladimir Lazar, Georges Bismuth, Salem Chouaib, and Fathia Mami-Chouaib
J. Exp. Med. 2007 204: 559-570. Published online Feb 26 2007, 10.1084/jem.20061524. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

The fibrin-derived {gamma}377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
Ryan A. Adams, Jan Bauer, Matthew J. Flick, Shoana L. Sikorski, Tal Nuriel, Hans Lassmann, Jay L. Degen, and Katerina Akassoglou
J. Exp. Med. 2007 204: 571-582. Published online Mar 5 2007, 10.1084/jem.20061931. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Chul-Su Yang, Dong-Seok Lee, Chang-Hwa Song, Se-Jin An, Shengjin Li, Jin-Man Kim, Cuk Seong Kim, Dae Goon Yoo, Byeong Hwa Jeon, Hee-Young Yang, Tae-Hoon Lee, Zee-Won Lee, Jamel El-Benna, Dae-Yeul Yu, and Eun-Kyeong Jo
J. Exp. Med. 2007 204: 583-594. Published online Feb 26 2007, 10.1084/jem.20061849. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
Jia Zhu, David M. Koelle, Jianhong Cao, Julio Vazquez, Meei Li Huang, Florian Hladik, Anna Wald, and Lawrence Corey
J. Exp. Med. 2007 204: 595-603. Published online Feb 26 2007, 10.1084/jem.20061792. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Stromal cell–derived factor 1 promotes angiogenesis via a heme oxygenase 1–dependent mechanism
Jessy Deshane, Sifeng Chen, Sergio Caballero, Anna Grochot-Przeczek, Halina Was, Sergio Li Calzi, Radoslaw Lach, Thomas D. Hock, Bo Chen, Nathalie Hill-Kapturczak, Gene P. Siegal, Jozef Dulak, Alicja Jozkowicz, Maria B. Grant, and Anupam Agarwal
J. Exp. Med. 2007 204: 605-618. Published online Mar 5 2007, 10.1084/jem.20061609. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R{alpha} mutant mice
Lisa C. Osborne, Salim Dhanji, Jonathan W. Snow, John J. Priatel, Melissa C. Ma, M. Jill Miners, Hung-Sia Teh, Mark A. Goldsmith, and Ninan Abraham
J. Exp. Med. 2007 204: 619-631. Published online Feb 26 2007, 10.1084/jem.20061871. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell–like diffuse large B cell lymphoma
Georg Lenz, Inga Nagel, Reiner Siebert, Anna V. Roschke, Warren Sanger, George W. Wright, Sandeep S. Dave, Bruce Tan, Hong Zhao, Andreas Rosenwald, Hans Konrad Muller-Hermelink, Randy D. Gascoyne, Elias Campo, Elaine S. Jaffe, Erlend B. Smeland, Richard I. Fisher, W. Michael Kuehl, Wing C. Chan, and Louis M. Staudt
J. Exp. Med. 2007 204: 633-643. Published online Mar 12 2007, 10.1084/jem.20062041. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion
Menno C. van Zelm, Tomasz Szczepanski, Mirjam van der Burg, and Jacques J.M. van Dongen
J. Exp. Med. 2007 204: 645-655. Published online Feb 20 2007, 10.1084/jem.20060964. [Abstract] [Full Text] [PDF]  

Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice
Youchun Jiang, Corey Reynolds, Chang Xiao, Wenke Feng, Zhanxiang Zhou, Walter Rodriguez, Suresh C. Tyagi, John W. Eaton, Jack T. Saari, and Y. James Kang
J. Exp. Med. 2007 204: 657-666. Published online Mar 5 2007, 10.1084/jem.20061943. [Abstract] [Full Text] [PDF]  

Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell–mediated liver damage
Claire Dunn, Maurizia Brunetto, Gary Reynolds, Theodoros Christophides, Patrick T. Kennedy, Pietro Lampertico, Abhishek Das, A. Ross Lopes, Persephone Borrow, Kevin Williams, Elizabeth Humphreys, Simon Afford, David H. Adams, Antonio Bertoletti, and Mala K. Maini
J. Exp. Med. 2007 204: 667-680. Published online Mar 12 2007, 10.1084/jem.20061287. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76
Vincenzo Di Bartolo, Benjamin Montagne, Mogjiborahman Salek, Britta Jungwirth, Florent Carrette, Julien Fourtane, Nathalie Sol-Foulon, Frédérique Michel, Olivier Schwartz, Wolf D. Lehmann, and Oreste Acuto
J. Exp. Med. 2007 204: 681-691. Published online Mar 12 2007, 10.1084/jem.20062066. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

 

CORRECTIONS:Back

Peroxisome proliferator–activated receptor (PPAR){alpha} expression in T cells mediates gender differences in development of T cell–mediated autoimmunity
Shannon E. Dunn, Shalina S. Ousman, Raymond A. Sobel, Luis Zuniga, Sergio E. Baranzini, Sawsan Youssef, Andrea Crowell, John Loh, Jorge Oksenberg, and Lawrence Steinman
J. Exp. Med. 2007 204: 693. Published online Mar 19 2007, 10.1084/jem.20061839020807c. [Full Text] [PDF]  

 

FROM THE JCB:Back

PPAR{gamma}1 attenuates cytosol to membrane translocation of PKC{alpha} to desensitize monocytes/macrophages
Andreas von Knethen, Mathias Soller, Nico Tzieply, Andreas Weigert, Axel M. Johann, Carla Jennewein, Roman Köhl, and Bernhard Brüne [Full Text]  

Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development
Chunxi Ge, Guozhi Xiao, Di Jiang, and Renny T. Franceschi [Full Text]  

Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis
A. Wayne Orr, Rebecca Stockton, Michael B. Simmers, John M. Sanders, Ian J. Sarembock, Brett R. Blackman, and Martin Alexander Schwartz [Full Text]  

Syk, c-Src, the {alpha}vß3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
Wei Zou, Hideki Kitaura, Jennifer Reeve, Fanxin Long, Victor L.J. Tybulewicz, Sanford J. Shattil, Mark H. Ginsberg, F. Patrick Ross, and Steven L. Teitelbaum [Full Text]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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