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COVER PICTURE: The cover highlights the first publication, 70 years ago in The Journal of Experimental Medicine, on experimental encephalomyelitis. Lawrence Steinman comments on the long-standing durability of this model in experimental medicine, to highlight the original paper by Kuchroo and colleagues on a new experimental approach to acute optic neuritis. See related articles by Steinman, pp.(pages 1065-1070), and by Bettelli et al., pp. (pages 1073-1081).
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