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The Journal of Experimental Medicine
196
4
Pro–B cell lymphomas develop in mice deficient in both p53 and DNA repair proteins of the non-homologous end-joining pathway. These tumors are all characterized by nonreciprocal translocations juxtaposing the c-myc oncogene and the IgH intronic enhancer as well as amplification of both genes. The top panel illustrates the rearrangement of chromosome 12 (red-containing IgH locus) and chromosome 15 (green-containing c-myc locus). Coamplification of the IgH (red) and c-myc (yellow) loci occurs on the der(15) (bottom panel), although this chromosome is not capped by chromosome 15 subtelomeric sequences (green). See related article by Difilippantonio et al., pp.
469-480.
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