About the Cover
The Journal of Experimental Medicine
194
9
A family of molecules called cyclins (A, B, D, and E) that associate with and activate cyclin-dependent kinases (cdks) controls specific checkpoints in the cell cycle. Deregulated expression of cyclins and/or cdks may lead to aberrant cell growth and a malignant phenotype. The cover shows deregulated expression of cyclin B1 in a squamous cell carcinoma of the head and neck (SCCHN). Immunostaining of the tissue section with anti-cyclin B1 antibody (brown color) reveals overexpression of cyclin B1 protein in tumor cells and its location in the cytoplasm rather than the nucleus. Peptides derived from cyclin B1, eluted from HLA class I molecules of tumor cells, are targets for tumor-specific cytotoxic T cells. Patients with tumors that overexpress cyclin B1 have circulating T cells specific for multiple peptides derived from this molecule. See related article in this issue by Kao et al., pp.
1313-1323.
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