About the Cover
The Journal of Experimental Medicine
193
9
Cover picture: Host cell invasion by Trypanosoma cruzi trypomastigotes is inhibited by expression of soluble synaptotagmin VII C2A domain. Shown is an untransfected NRK cell containing two intracellular parasites (bottom; nuclear and kinetoplast staining in blue) and a cell transfected with synaptotagmin C2A fused to green fluorescent protein (top; green cytosolic staining). An incompletely internalized trypomastigote (extracellular portions of the parasite are stained with antibodies in red) is seen associated with the transfected cell. The authors demonstrate that T. cruzi utilizes the lysosomal exocytic pathway regulated by synaptotagmin VII to enter host cells. See related article in this issue by Caler et al., pp.
1097-1104.
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