About the Cover
The Journal of Experimental Medicine
193
8
Cover picture: Perivascular brain macrophages and not parenchymal microglia are the major cell type productively infected by simian immunodeficiency virus (SIV) in rhesus macaques. Perivascular macrophages are CD14 and CD45 positive and can thus be distinguished from parenchymal microglia. Multilabel confocal microscopy demonstrates that essentially all of the SIV-infected (p28) cells (green) are CD14-positive (blue) perivascular macrophages. The viral proteinŠ positive perivascular macrophages are seen near a central nervous system vessel (stained for glucose transporter 1 [Glut-1], red). See related article in this issue by Williams et al., pp.
905-915.
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