About the Cover
The Journal of Experimental Medicine
193
6
Cover picture: Depletion of colony-stimulating factor (CSF)-1 reduces leukocytic infiltration in mammary tumors and delays tumor progression to malignancy. Bottom panel (with CSF-1) shows a typical leukocytic infiltration site adjacent to the mammary tumor of a wild-type polyoma middle T antigen (PyMT) mouse at 9 wk of age. Cells with the morphology of granulocytes, mast cells, and monocyte-like cells were found in the site, and the tumor acini adjacent to the infiltrate displayed disrupted boundaries. Top panel (without CSF-1): very few leukocytes were observed in the vicinity of mammary tumors in CSF-1-depleted PyMT mice at 9 wk of age. The reduction of leukocytic infiltration in the tumors of these mice correlated with a delayed tumor progression to malignancy. See related article in this issue by Lin et al., pp.
727-739.
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