About the Cover
The Journal of Experimental Medicine
193
3
Cover picture: Low power micrographs of individual Mycobacterium tuberculosis-induced lung lesions in wild-type mice (upper right) and mice deficient in a capacity to generate CD8 T cell-mediated immunity (class I-/-; upper left), CD4 T cell-mediated immunity (class II-/-; lower right), or either type of immunity (TCR-alpha/beta-/-; lower left). The mice were infected by aerosol with 102 M. tuberculosis 50 d earlier. The sections are stained for inducible nitric oxide synthase (NOS2), an enzyme necessary for successful expression of immunity and an indicator of IFN-gamma-mediated macrophage activation. The brown NOS2 reaction product is located in cells in macrophage-dominated regions of the lesions, but not in lymphoid regions (dark blue). Similarities between the lesions of wild-type and class I-/- mice are in keeping with the ability of both types of mice to eventually control infection and to survive beyond 230 d. Class II-/- and TCR-alpha/beta-/- mice failed to control infection and died much earlier. See related article in this issue by Mogues et al., pp.
271-280.
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