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The Journal of Experimental Medicine 193 2 Cover picture: The NK cell C-type lectin­like receptor Ly49A (ribbon diagram) recognizes MHC class I (surface diagram) on target cells to inhibit NK cell cytotoxicity. The crystal structure of the Ly49A­MHC class I complex revealed two possible binding modes for dimeric Ly49A (colored light and dark blue). Critical residues required for the Ly49A­MHC class I interaction, which are colored red or orange, are found in alpha1, alpha2, and alpha3 domains of MHC class I. beta2-microglobulin (colored pink) contributes to the species-specificity of the interaction. Ly49A binds to a concave region of MHC class I that includes alpha1, alpha2, and alpha3 domains of the heavy chain and beta2-microglobulin to inhibit NK cell cytotoxicity. See related article in this issue by Matsumoto et al., pp. 147-157.
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