About the Cover
The Journal of Experimental Medicine
193
12
In eukaryotes, DNA associates with histones to form nucleosomes. Both the extensive histoneÐDNA contacts in individual nucleosomes and the folding of the chain of nucleosomes into higher order chromatin fibers limit the accessibility of DNA to transcription factors. The drawing shows a nucleosomal chain with accessible and inaccessible binding sites (in red) for the transcription factor nuclear factor (NF)-kappaB. Several inflammatory stimuli trigger the nuclear relocalization of NF-kappaB. Regulation of NF-kappaB site accessibility through acetylation of nucleosomal histones contributes to control the specificity of NF-kappaBÐdependent transcription. The ability of individual stimuli to make NF-kappaB sites accessible before loss of the transcription factor from the nucleus may dictate which NF-kappaBÐdependent genes are transcribed during an acute NF-kappaB response. See related article in this issue by Saccani et al., pp.
1351-1359,
respectively. Cover design by Bob Crimi.
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