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The Journal of Experimental Medicine 193 1 Cover picture: Transgenic mice expressing the high affinity IgE receptor (FcepsilonRI) with a "humanized" cell distribution display increased colon levels of interleukin 4, which leads to an increased intestinal permeability, thus allowing higher levels of bacterial translocation toward mesenteric lymph nodes compared to wild-type (WT) animals, expressing FcepsilonRI only on mast cells and basophils, and to FcepsilonRI-deficient animals. After hapten-induced colitis, MayGrünwald/Giemsa staining of colon sections shows that transgenic mice also display intense mucosal necrosis and submucosal infiltration (left), while their WT counterparts develop milder symptoms (center). Strikingly, FcepsilonRI-deficient animals are virtually protected from induced intestinal inflammation (right). See related article in this issue by Dombrowicz et al., pp. 25-34.
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