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The Journal of Experimental Medicine 192 9 Cover picture: Infection of mammals with Trypanosoma brucei is characterized by upregulation of prostaglandin (PG) production, the mechanism of which is not well understood. It is now known that T. brucei synthesizes PGs from arachidonic acid (AA) and its metabolite, PGH2. The trypanosomal enzyme converting PGH₂ to PGF_2alpha has been identified. The image proposes a biosynthetic pathway of PGs from AA and PGH₂. The scanning electron micrograph shows the long, slender bloodstream-form trypanosome taken from rats and colored pink along with erythrocytes colored orange. See related article in this issue by Kubata et al., pp. 1327-1337
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