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Index of Online Supplemental Material for
J. Exp. Med. 10.1084/jem.20072000
Yamashita et al. • Figure S1 Phenotypic and functional characterization of Bmi1−/− Th2 cells.
• Figure S2 Impaired generation of memory Th1 cells from Bmi1−/− effector Th1 cells in BALB/c mice.
• Figure S3 Kinetic analysis of the number of Th2 cells after adoptive transfer of effector Th2 cells.
• Figure S4 Competitive analysis for memory Th2 cell generation from Bmi1+/+and Bmi1+/− effector Th2 cells under nonlymphopenic conditions.
• Figure S5 A competitive analysis for memory Th2 cell generation from Bmi1+/+and Bmi1−/− effector Th2 cells under lymphopenic conditions.
• Figure S6 Deletion of the p53 gene failed to restore the generation of Bmi1+/− memory Th2 cells.
• Figure S7 mRNA expression of Noxa in Bmi1+/+ and Bmi1−/− effector Th1, Th2, Tc1, and Tc2 cells was determined by a quantitative RT-PCR system.
• Figure S8 mRNA expression of the Ink4a/Arf and Noxa in Bmi1+/+, Bmi1+/−, and Bmi1−/− effector Th2 cells was determined by quantitative RT-PCR.
• Figure S9 Binding of Bmi1 at the Noxa gene locus in effector Th1 and Th2 cells.
• Figure S10 Histone modifications (Ac-H3-K9/K14; acetylation of histone H3-K9/K14 and Me3-H3-K27; tri-methylation of histone H3-K27) at the Noxa gene locus in Bmi1+/+ and Bmi1−/− effector Th1 cells.
• Figure S11 Binding of Dnmt1 at the Noxa gene locus in effector Th1 cells.
• Figure S12 Histone modifications (Ac-H3-K9/K14; acetylation of histone H3-K9/K14, Me3-H3-K4; tri-methylation of histone H3-K4 and Me3-H3-K27; tri-methylation of histone H3-K27) at the Noxa gene locus after 5-Aza-2’-deoxycytidine (5-Aza) treatment.
• Figure S13 Noxa mRNA expression and the binding of Bmi1 at the Noxa gene locus in effector Th1 cells after 5-Aza treatment.
• Figure S14 The mRNA expression of Noxa in Th2 cells treated with a DNA methyltransferase inhibitor was determined by a quantitative RT-PCR system.
• Table S1 (PDF)
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