The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 96, 549-554, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INHIBITION BY CORTISONE OF THE CYTOTOXIC ACTIVITY OF PPD ON TUBERCULIN-HYPERSENSITIVE CELLS IN TISSUE CULTURE

Robert H. Leahy 1 and Herbert R. Morgan M.D.1

1 From the Department of Bacteriology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Using the roller tube method of tissue culture, it has been shown that cortisone and compound F inhibit the cytotoxic action of PPD upon macrophages from the splenic tissue of tuberculous guinea pigs. Pretreatment of the cells for 24 hours with hormones before exposure to PPD was found to be essential. Estrone and desoxycorticosterone glucoside had no protective activity.

Certain advantages of the tissue culture method in studies of tuberculin hypersensitivity and possible mechanisms and implications of this protective action of cortisone are discussed.

 Submitted on July 23, 1952


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