The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 94, 111-121, Copyright, 1951, by The Rockefeller Institute for Medical Research New York

ARTICLE

ADAPTATION OF A LANSING STRAIN OF POLIOMYELITIS VIRUS TO NEWBORN MICE

Jordi Casals M.D.1, Peter K. Olitsky M.D.1, and Ralph O. Anslow D.V.M. Major1

1 From the Laboratories of The Rockefeller Institute for Medical Research

By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniformly short and regular incubation period.

Submitted on April 2, 1951


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