The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 89, 233-243, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE NATURE OF THE VIRUS RECEPTORS OF RED CELLS : IV. EFFECT OF SODIUM PERIODATE ON THE ELUTION OF INFLUENZA VIRUS FROM RED CELLS



George K. Hirst M.D.1

1 From the Division of Infectious Diseases, The Public Health Research Institute of The City of New York

Influenza virus, treated with sodium periodate, was adsorbed well on red cells but lacked the capacity for spontaneous elution. Heated virus was eluted from red cells by the action of cholera vibrio filtrate, unheated influenza virus, and to a small extent by heating at 56°C. Periodate-treated virus was not elutable by these methods but was liberated by exposure of the adsorbing cells to concentrations of sodium chloride of 5 to 10 per cent. This treatment had no effect on elution of heated virus.

Submitted on November 5, 1948


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