The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 87, 339-351, Copyright, 1948, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON SCRUB TYPHUS (TSUTSUGAMUSHI DISEASE) : III. HETEROGENICITY OF STRAINS OF R. TSUTSUGAMUSHI AS DEMONSTRATED BY CROSS-VACCINATION STUDIES



Fred L. Rights Ph.D.1, Joseph E. Smadel M.D.1, and Assisted by Elizabeth B. Jackson

1 From the Department of Virus and Rickettsial Diseases, Army Medical Department Research and Graduate School, Washington, D. C., and the Department of Bacteriology, College of Physicians and Surgeons, Columbia University, New York

Antigenic differences among strains of R. tsutsugamushi are sufficiently great that vaccines prepared from certain strains fail to induce resistance in mice to infection with other strains. Although the results of cross-vaccination tests indicate varying degrees of relationship between a number of the strains, there is no correlation between source of the rickettsia and antigenic pattern of the agent.

Submitted on January 5, 1948


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