The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 85, 623-646, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE MODIFYING EFFECTS OF CERTAIN SUBSTANCES OF BACTERIAL ORIGIN ON THE COURSE OF INFECTION WITH PNEUMONIA VIRUS OF MICE (PVM)

Frank L. Horsfall Jr. M.D.1 and Maclyn McCarty M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

Evidence is presented which indicates that certain polysaccharide preparations derived from various bacterial species, as well as similar materials not of bacterial origin, are capable of lessening the severity of infection with pneumonia virus of mice (PVM) and inhibiting multiplication of the virus in mouse lungs infected with this agent. It seems probable that modification with respect to the virus is mediated by a substance which may be polysaccharide in nature.

Submitted on February 24, 1947


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