The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 81, 85-92, Copyright, 1945, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON MENINGOCOCCAL INFECTION : XIII. CORRELATION BETWEEN ANTIPOLYSACCHARIDE AND THE ANTIBODY WHICH PROTECTS MICE AGAINST INFECTION WITH TYPE I MENINGOCOCCI



Henry W. Scherp Ph.D.1 and Geoffrey Rake M.B., B.S.1

1 From the Department of Bacteriology, The University of Rochester School of Medicine and Dentistry, Rochester, New York, and the Division of Microbiology, The Squibb Institute for Medical Research, New Brunswick, New Jersey

Absorption tests indicated that the protective antibody (Type I) in four antimeningococcal horse sera corresponded closely to one of the components of the polysaccharide preparation previously isolated by the authors from Type I meningococci. This antibody was, however, a minor fraction in the three therapeutic sera tested, being secondary in amount to non-protective antibody corresponding to another component of the polysaccharide preparation, plus antibody corresponding to agar. In one case, removal of the agar-antibody diminished the protective titer by 30 per cent.

Submitted on September 6, 1944


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