The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 78, 321-326, Copyright, 1943, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON HERPETIC INFECTION IN MICE : III. THE VISCERAL LESIONS IN SUCKLING MICE



Howard B. Slavin M.D.1 and George Packer Berry M.D.1

1 From the Departments of Bacteriology and Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Intranasal instillation of herpes virus in suckling mice results in specific lesions widely distributed in the viscera. The lungs are infected by aspiration of the virus. Virus disseminated by way of the blood establishes itself in endothelium in certain situations where parenchymal lesions result by direct spread from the vascular foci. Evidence of blood-borne infection was found frequently in the liver and spleen, less frequently in the suprarenals, and, in one instance, in the bone marrow. Renal infection appeared to be uriniferous. Lymph carriage of the virus also occurs, and lymph nodes draining infected areas were often found to contain herpetic inclusion bodies. Herpes virus seems incapable of invading the central nervous system of suckling mice by the vascular route.

Submitted on May 1, 1943


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