The Journal of Experimental Medicine, Vol 65, 373-392,
Copyright, 1937, by The Rockefeller Institute for Medical Research New York
THE LYMPHATICS AND LYMPH FLOW IN THE EDEMATOUS SKIN OF HUMAN BEINGS WITH CARDIAC AND RENAL DISEASE
Philip D. McMaster M.D.1
1 From the Laboratories of The Rockefeller Institute for Medical Research
Local intradermal injections of dye have disclosed the fact that the skin lymphatics in regions of cardiac edema are patent, full of fluid and much widened. Intercommunication between them is ready and dye escapes from them more rapidly than from the vessels of normal skin. A retrograde distribution of dye by way of the lymphatics often occurs and it may pass unseen along the deeper channels to emerge in the skin at unexpected, distant situations. A valvular incompetence of the lymphatics consequent on dilatation would appear to be the cause of these phenomena. In regions of cardiac edema lymph stagnates, despite the fact that the channels are open.
In nephritic edema the lymphatic capillaries are wider than normal but not as wide as in cardiac edema. No sign of incompetency of the valves is to be observed. Instead lymph flow is considerably greater than normal, even when edema fluid is accumulating. It was noted to be greater in the periods of fluid equilibrium also and extraordinarily rapid in periods of diuresis.
Submitted on April 24, 1936
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