The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 65, 339-345, Copyright, 1937, by The Rockefeller Institute for Medical Research New York

ARTICLE

ANAPHYLACTIC SENSITIZATION WITH CHEMICALLY DEFINITE COMPOUNDS

H. E. Fierz 1, W. Jadassohn 1, and W. Stoll 1

1 From the Chemical Laboratory, Federal Polytechnic Institute, and the Dermatological Clinic of the University of Zurich, Zurich, Switzerland

Injection of sodium atoxyl-diazoamino-sulfoanthranilate into guinea pigs produces an anaphylactic hypersensitiveness to the corresponding azoprotein (Schultz-Dale test). This leads to the conclusion that the injected sodium atoxyl-diazoamino-sulfoanthranilate first decomposes and then couples in vivo with the body protein to form the corresponding azoprotein and that therefore it is this compound, produced within the organism itself, which sensitizes.

Submitted on September 23, 1936


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