The Journal of Experimental Medicine
Torrey Pines Biolabs
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The Journal of Experimental Medicine, Vol 64, 79-96, Copyright, 1936, by The Rockefeller Institute for Medical Research New York

ARTICLE

SEROLOGICAL REACTIONS WITH A VIRUS CAUSING RABBIT PAPILLOMAS WHICH BECOME CANCEROUS : II. TESTS OF THE BLOOD OF ANIMALS CARRYING VARIOUS EPITHELIAL TUMORS



John G. Kidd M.D.1, J. W. Beard M.D.1, and Peyton Rous M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

The serum of a rabbit with large cancers resulting from the transplantation of a squamous cell carcinoma that had arisen from a virusinduced papilloma, possessed the power to neutralize the virus, and so too in less degree did that of an animal of the same transplantation series in which a small nodule had developed. The sera of rabbits carrying tar papillomas or the Brown-Pearce carcinoma proved wholly devoid of effect on the virus. The implantation of Brown-Pearce tumor material mixed with virus did not lead to an enduring establishment of the latter in the resulting growths, nor to any immediate changes in their morphological character.

The significance of the facts is discussed.

 Submitted on April 28, 1936


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