The Journal of Experimental Medicine
Torrey Pines Biolabs
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The Journal of Experimental Medicine, Vol 63, 795-801, Copyright, 1936, by The Rockefeller Institute for Medical Research New York

ARTICLE

PROTHROMBIN DEFICIENCY THE CAUSE OF BLEEDING IN BILE FISTULA DOGS

W. B. Hawkins M.D.1 and K. M. Brinkhous M.D.1

1 From the Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, N. Y., and the Department of Pathology, State University of Iowa College of Medicine, Iowa City

The bleeding tendency that develops in bile fistula dogs, completely or partially deprived of bile, is due to a prothrombin deficiency of the blood plasma. However, a relatively low prothrombin level may exist in these animals without the occurrence of spontaneous hemorrhage. The prothrombin level may remain within the limits of normal if sufficient bile has been fed. In these cases no disturbance in blood clotting occurs.

Submitted on February 27, 1936


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