The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 1191K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sabin, F. R.
Right arrow Articles by Thomas, R. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Sabin, F. R.
Right arrow Articles by Thomas, R. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 62, 751-769, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

CELLULAR REACTIONS TO WAX-LIKE MATERIALS FROM ACID-FAST BACTERIA : THE UNSAPONIFIABLE FRACTION FROM THE TUBERCLE BACILLUS, STRAIN H-37



F. R. Sabin M.D.1, K. C. Smithburn M.D.1, and R. M. Thomas M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. The unsaponifiable fractions of the Mycobacteria, though insoluble in water and extremely stable chemical compounds, are nevertheless remarkable stimulants of cells.

2. They give rise to new monocytes which surround these waxes and then fuse into giant cells which engulf them.

3. The property of acid-fastness of the waxes makes it possible to identify them within the giant cells which have phagocytized them.

4. Within the foreign body giant cells the waxes are slowly disintegrated. They appear not to damage the cells which engulf them, and hence one may infer that they take no part in caseation.

5. They have no effect on the resistance of the host.

 Submitted on July 8, 1935


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS