The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 62, 485-503, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

LIPOIDS AND IMMUNOLOGICAL REACTIONS : I. THE RELATION OF PHOSPHOLIPINS TO THE TYPE-SPECIFIC REACTIONS OF ANTIPNEUMOCOCCUS HORSE AND RABBIT SERA



Frank L. Horsfall Jr. M.D.1 and Kenneth Goodner Ph.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

It has been demonstrated that the removal of lipoids from Type I antipneumococcus horse serum causes a loss of the visible phenomena of type specific agglutination and precipitation, and in the case of rabbit serum a marked reduction in these properties. Initial activity of the type specific antibody can be restored to extracted immune horse serum by the addition of lecithin, and to rabbit serum by the addition of cephalin. The significance of these observations in respect to the relation of phospholipins to the type specific reactions of antipneumococcus serum is discussed.

Submitted on June 12, 1935


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