The Journal of Experimental Medicine
BioLegend: New Th17, Treg Tools
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 1438K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coburn, A. F.
Right arrow Articles by Pauli, R. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Coburn, A. F.
Right arrow Articles by Pauli, R. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 62, 159-178, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE IMMUNE RESPONSE OF THE RHEUMATIC SUBJECT AND ITS RELATIONSHIP TO ACTIVITY OF THE RHEUMATIC PROCESS : III. OBSERVATIONS ON THE REACTIONS OF A RHEUMATIC GROUP TO AN EPIDEMIC INFECTION WITH HEMOLYTIC STREPTOCOCCUS OF A SINGLE TYPE



Alvin F. Coburn M.D.1 and Ruth H. Pauli 1

1 From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

This study of an isolated colony showed that of seven children who escaped the epidemic streptococcus infection none developed rheumatic symptoms; and that of seventeen children who contracted the epidemic streptococcus infection, fourteen developed acute rheumatism and three showed no recognizable rheumatic manifestations.

The seven children who failed to contract infection with Streptococcus hemolyticus showed clearly that susceptible individuals may live in dose association with an epidemic of acute rheumatism, develop no rise in antistreptolysin titer and maintain excellent health.

The patient with congenital heart disease demonstrated that a non-rheumatic subject may be infected with a highly effective strain of hemolytic streptococcus, and develop a typical antibody response, yet escape all rheumatic manifestations.

The two patients who, although infected with the epidemic strain, failed to show any antibody response, also failed to develop rheumatic recrudescences.

Environmental, dietary, age and the other factors investigated did not appear to be significant in this outbreak of acute rheumatism.

Three factors appeared to determine the development of the fourteen recrudescences: (1) infection with a highly effective agent; (2) the disease pattern, peculiar to each rheumatic subject; (3) the intensity of the immune response of the patient as indicated by the rise in antistreptolysin titer.

 Submitted on April 15, 1935


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS