STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

doi:10.1084/jem.61.5.643

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The Journal of Experimental Medicine, Vol 61, 643-656, Copyright, 1935, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

K. Landsteiner M.D.¹ and John Jacobs M.D.¹

¹ From the Laboratories of The Rockefeller Institute for Medical Research

Experiments on the sensitization of guinea pigs with simplechemical compounds are described. Positive effects were obtainedby the administration of small quantities, namely fractionsof milligrams, with 1:2:4 chlorodinitrobenzene, p-nitrosodimethylaniline,1:2:4 trinitrobenzene, picryl chloride, four dichlorodinitrobenzenes,and a number of other aromatic compounds. Several substanceschemically similar to those enumerated gave negative results.The first named compound is known to produce hypersensitivenessin human beings, a large number of cases having been observedin factory workers.

The mechanism of these effects is discussed.

Submitted on January 24, 1935

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