THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN

doi:10.1084/jem.60.5.559

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The Journal of Experimental Medicine, Vol 60, 559-574, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN

Francis F. Schwentker M.D.¹ and Thomas M. Rivers M.D.¹

¹ From the Hospital of The Rockefeller Institute for Medical Research

Rabbits injected with fresh emulsions of homologous brain developedfew or no antibodies capable of fixing complement in the presenceof aqueous emulsions or alcoholic extracts of rabbit brain.Complement-fixing antibodies, however, were produced in rabbitsby means of injections (1) of sterile emulsions of homologousbrain which had been allowed to stand at room temperature for5 to 30 days and (2) of emulsions of homologous brain experimentallyinfected with vaccine virus. The antisera that were producedfollowing injections of emulsions of autolyzed homologous brainwere shown by absorption tests to contain both specific andnon-specific antibodies. The specific brain antigen was foundto be approximately six times as abundant in the white matteras in the grey. It was almost absent from the brain of fetaland newly born rabbits, but increased in amount with the ageof the animal to reach a maximum concentration at maturity.The specific antigen seemed to parallel the myelin content ofbrain tissue.

Submitted on July 29, 1934

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