BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS: III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H37)

doi:10.1084/jem.60.4.515

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The Journal of Experimental Medicine, Vol 60, 515-540, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : III. DISSOCIATION AND PATHOGENICITY OF THE R AND S VARIANTS OF THE HUMAN TUBERCLE BACILLUS (H₃₇)

W. Steenken Jr. ¹, W. H. Oatway Jr. M.D.¹, and S. A. Petroff Ph.D.¹

¹ From the Research and Clinical Laboratory, Trudeau Sanatorium, Trudeau

1. The H₃₇ strain of human tubercle bacillus has been dissociatedinto two variants,—the R, or avirulent, and the S, or virulent,variants.

2. When their dissociation is complete, colony morphologyfor each is distinctive and typical.

3. The morphology of theindividual bacilli of the two variants is different and characteristic.

4.The R variant develops best in an acid medium; the S developsbest in an alkaline medium.

5. A method of assortment to facilitatethe procedure of forced dissociation has been described.

6.The difference in virulence has been proven by observationson the pathogenesis of the variants.

Submitted on July 29, 1934

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