The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 59, 641-667, Copyright, 1934, by The Rockefeller Institute for Medical Research New York

ARTICLE

EXPERIMENTAL TYPE III PNEUMOCOCCUS PNEUMONIA IN MONKEYS : II. TREATMENT WITH AN ENZYME WHICH DECOMPOSES THE SPECIFIC CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III



Thomas Francis Jr. M.D.1, Edward E. Terrell M.D.1, René Dubos Ph.D.1, and Oswald T. Avery M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

The effects of specific enzyme therapy upon experimental Type III pneumococcus pneumonia in monkeys were studied by comparing the course and outcome of the disease in treated animals with that in animals which received no therapeutic aid. Enzyme treatment was found to exert a distinctly favorable influence upon the experimental pneumonia. Treatment was followed by cessation of spread of the pneumonic lesion, sterilization of the blood, and early recovery, except in animals in which the severity of the disease was extreme. While in the untreated animals a high incidence of empyema and pericarditis was observed, suppurative sequelae were apparently prevented by adequate enzyme therapy. The limitations of the therapeutic action of the specific enzyme in the presence of marked depression of the cellular reaction in infected animals are again emphasized.

Submitted on January 31, 1934


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