The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 54, 171-180, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

REACTION OF YOUNG AND ADULT RABBITS TO PNEUMOCOCCI INJECTED INTO THE SKIN

Jules Freund M.D1

1 From The Henry Phipps Institute, University of Pennsylvania, Philadelphia

1. Young and adult rabbits react differently to intracutaneous injection of virulent pneumococci. In adult rabbits a very extensive inflammation develops at the site of infection and bacteriemia and death occur only in a relatively few rabbits. Young rabbits fail to develop extensive inflammation and die with bacteriemia.

2. It is probable that the fate of the animals is influenced by the capacity to develop inflammation at the site of injection of pneumococci.

 Submitted on April 9, 1931


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