The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 53, 115-121, Copyright, 1931, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMUNITY FOLLOWING THE INJECTION OF MONKEYS WITH MIXTURES OF POLIOMYELITIS VIRUS AND CONVALESCENT HUMAN SERUM

C. P. Rhoads M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

1. Experiments are reported on the use of poliomyelitis virus neutralized by specific antiserum as an agent to induce active immunity against the experimental disease in monkeys.

2. The results indicate that protection can be conferred upon a certain number of the treated animals.

3. The neutralized material gave rise in no instance to symptoms of disease in the treated monkeys.

4. Active poliomyelitis virus, suitably neutralized by admixture with convalescent serum, was without pathogenic effect when given by repeated nasal instillations.

 Submitted on October 1, 1930


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