The Journal of Experimental Medicine, Vol 51, 23-26,
Copyright, 1930, by The Rockefeller Institute for Medical Research New York
THE EFFECT OF THE X-RAY ON THE NODULES OF VERRUGA PERUANA
Henry R. Muller M.D.1 and
Joseph R. Tyler 1
1 From the Laboratories of The Rockefeller Institute for Medical Research
The supposition that X-ray would affect the developing and the developed verruga nodules experimentally induced in the monkey, has proved correct. The experiments show that the early verruga nodules when exposed to a single, properly graduated dose of X-ray producing merely erythema of the skin, are inhibited in their evolution. Moreover, the skin of Macacus rhesus monkeys is modified by a single erythema dose of X-ray in such a way that infection of it with Bartonella bacilliformis is rendered more difficult.
These results are sufficiently striking to warrant the trial of X-ray in suitably guarded doses in the treatment of verruga nodules in man. Should the employment of convalescent serum influence the course of Carrion's disease favorably and the use of X-ray bring about a more certain and rapid devolution of verruga nodules in man, two practically applicable therapeutic measures will have been provided for the treatment of the two forms of the human disease.
Submitted on October 20, 1929
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