The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 36, 239-245, Copyright, 1922, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES UPON EXPERIMENTAL MEASLES : III. THE SYMPTOM-COMPLEX IN THE GUINEA PIG AND RABBIT FOLLOWING THE INTRATRACHEAL AND INTRAVENOUS INJECTIONS OF FILTERED NASOPHARYNGEAL SECRETIONS FROM CASES OF HUMAN MEASLES.



Charles W. Duval M.D.1 and Rigney D'Aunoy M.D.1

1 From the Department of Pathology of Tulane University of Louisiana, New Orleans.

1. There is present as a causal agent in the nasopharyngeal secretions of measles cases a filter-passing virus.

2. The rabbit and the guinea pig react specifically to the intratracheal and intracirculatory injections of filtered nasopharyngeal secretions secured from cases of human measles.

3. Enanthem, exanthem, and pyrexial disturbances characterize this specific reaction in the rabbit; in the guinea pig the reaction manifests itself by pyrexia, marked leucopenia, and grave nephritis in the fatal cases.

 Submitted on February 26, 1922


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