The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 35, 469-473, Copyright, 1922, by The Rockefeller Institute for Medical Research New York

ARTICLE

EXPERIMENTAL STUDIES ON THE ETIOLOGY OF TYPHUS FEVER : IV. IMMUNIZING AND TOXIC AGENTS FOUND OCCASIONALLY IN FILTRATES OF TYPHUS-INFECTED TISSUES.



Peter K. Olitsky M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

In the filtrates of typhus-infected tissues of guinea pigs can be occasionally found a substance which produces in these animals thermic reactions, lesions characteristic of experimental typhus, and, still less frequently, immunity to later injections of active virus. The general indications are that this substance is not a living organism.

Submitted on November 6, 1921


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