The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 17 March 2003. doi:10.1084/jem.20020906
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 159K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wood, N.
Right arrow Articles by Grusby, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wood, N.
Right arrow Articles by Grusby, M. J.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*OMIM
*UniGene
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© Rockefeller University Press, 0022-1007/2003/3/703 $5.00
The Journal of Experimental Medicine, Volume 197, Number 6, 703-709

Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor {alpha} 2

Nancy Wood1, Matthew J. Whitters2, Bruce A. Jacobson1, JoAnn Witek2, Joseph P. Sypek1, Marion Kasaian1, Michael J. Eppihimer1, Michelle Unger1, Takashi Tanaka3, Samuel J. Goldman1, Mary Collins2, Debra D. Donaldson1 and Michael J. Grusby3

1 Department of Respiratory Disease, Wyeth Research, Cambridge, MA 02140
2 Department of Musculoskeletal Sciences, Wyeth Research, Cambridge, MA 02140
3 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115

Address correspondence to Debra D. Donaldson, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140. Phone: 617-665-5549; Fax: 617-665-5584; E-mail: ddonaldson{at}wyeth.com

Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. At least two distinct receptor components, IL-4 receptor (R){alpha} and IL-13R{alpha}1, mediate the diverse actions of IL-13. We have recently described an additional high affinity receptor for IL-13, IL-13R{alpha}2, whose function in IL-13 signaling is unknown. To better appreciate the functional importance of IL-13R{alpha}2, mice deficient in IL-13R{alpha}2 were generated by gene targeting. Serum immunoglobulin E levels were increased in IL-13R{alpha}2-/- mice despite the fact that serum IL-13 was absent and immune interferon {gamma} production increased compared with wild-type mice. IL-13R{alpha}2–deficient mice display increased bone marrow macrophage progenitor frequency and decreased tissue macrophage nitric oxide and IL-12 production in response to lipopolysaccharide. These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13R{alpha}2 in regulating immune responses in wild-type mice.

Key Words: receptors • immunoglobulin E • interleukin 13 • knockout mice • nitric oxide


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS