FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that Induces FADD Phosphorylation and Inhibits Fas-mediated Jun NH2-terminal Kinase Activation

doi:10.1084/jem.192.8.1165

Published online 16 October 2000.

This Article

	Full Text
	Full Text (PDF, 505K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Rochat-Steiner, V.
	Articles by Tschopp, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Rochat-Steiner, V.
	Articles by Tschopp, J.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0022-1007/2000/10/1165/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 8, October 16, 2000 1165-1174

Original Article

FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that Induces FADD Phosphorylation and Inhibits Fas-mediated Jun NH₂-terminal Kinase Activation

Véronique Rochat-Steiner^a, Karin Becker^a, Olivier Micheau^a, Pascal Schneider^a, Kim Burns^a, and Jürg Tschopp^a
^a Institute of Biochemistry, University of Lausanne, BIL Biomedical Research Center, CH-1066 Epalinges, Switzerland

Correspondence to: Jürg Tschopp, Institute of Biochemistry, University of Lausanne, Ch. des Boveresses 155, CH-1066 Epalinges, Switzerland. Tel:41-21-692-5738 Fax:41-21-692-5705

Fas is a cell surface death receptor that signals apoptosis.Several proteins have been identified that bind to the cytoplasmicdeath domain of Fas. Fas-associated death domain (FADD), whichcouples Fas to procaspase-8, and Daxx, which couples Fas tothe Jun NH₂-terminal kinase pathway, bind independently to theFas death domain. We have identified a 130-kD kinase designatedFas-interacting serine/threonine kinase/homeodomain-interactingprotein kinase (FIST/HIPK3) as a novel Fas-interacting protein.Binding to Fas is mediated by a conserved sequence in the COOHterminus of the protein. FIST/HIPK3 is widely expressed in mammaliantissues and is localized both in the nucleus and in the cytoplasm.In transfected cell lines, FIST/HIPK3 causes FADD phosphorylation,thereby promoting FIST/HIPK3–FADD–Fas interaction.Although Fas ligand–induced activation of Jun NH₂-terminalkinase is impaired by overexpressed active FIST/HIPK3, celldeath is not affected. These results suggest that Fas-associatedFIST/HIPK3 modulates one of the two major signaling pathwaysof Fas.

Key Words: Fas/CD95, apoptosis, kinase, Jun NH₂-terminal kinase, signaltransduction

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Kasler, H. G., Verdin, E. (2007). Histone Deacetylase 7 Functions as a Key Regulator of Genes Involved in both Positive and Negative Selection of Thymocytes. Mol. Cell. Biol. 27: 5184-5200 [Abstract] [Full Text]
Landais, S., Landry, S., Legault, P., Rassart, E. (2007). Oncogenic Potential of the miR-106-363 Cluster and Its Implication in Human T-Cell Leukemia. Cancer Res. 67: 5699-5707 [Abstract] [Full Text]
Lan, H.-C., Li, H.-J., Lin, G., Lai, P.-Y., Chung, B.-c. (2007). Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation. Mol. Cell. Biol. 27: 2027-2036 [Abstract] [Full Text]
Lanahan, A. A., Chittenden, T. W., Mulvihill, E., Smith, K., Schwartz, S., Simons, M. (2006). Synectin-dependent gene expression in endothelial cells. Physiol. Genomics 27: 380-390 [Abstract] [Full Text]
Isono, K., Nemoto, K., Li, Y., Takada, Y., Suzuki, R., Katsuki, M., Nakagawara, A., Koseki, H. (2006). Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.. Mol. Cell. Biol. 26: 2758-2771 [Abstract] [Full Text]
Chen, G., Bhojani, M. S., Heaford, A. C., Chang, D. C., Laxman, B., Thomas, D. G., Griffin, L. B., Yu, J., Coppola, J. M., Giordano, T. J., Lin, L., Adams, D., Orringer, M. B., Ross, B. D., Beer, D. G., Rehemtulla, A. (2005). Phosphorylated FADD induces NF-{kappa}B, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc. Natl. Acad. Sci. USA 102: 12507-12512 [Abstract] [Full Text]
Wu, X., Ahn, E.-Y., McKenna, M. A., Yeo, H., McDonald, J. M. (2005). Fas Binding to Calmodulin Regulates Apoptosis in Osteoclasts. J. Biol. Chem. 280: 29964-29970 [Abstract] [Full Text]
Venables, J. P., Bourgeois, C. F., Dalgliesh, C., Kister, L., Stevenin, J., Elliott, D. J. (2005). Up-regulation of the ubiquitous alternative splicing factor Tra2{beta} causes inclusion of a germ cell-specific exon. Hum Mol Genet 14: 2289-2303 [Abstract] [Full Text]
Li, X., Zhang, R., Luo, D., Park, S.-J., Wang, Q., Kim, Y., Min, W. (2005). Tumor Necrosis Factor {alpha}-induced Desumoylation and Cytoplasmic Translocation of Homeodomain-interacting Protein Kinase 1 Are Critical for Apoptosis Signal-regulating Kinase 1-JNK/p38 Activation. J. Biol. Chem. 280: 15061-15070 [Abstract] [Full Text]
Gostissa, M., Morelli, M., Mantovani, F., Guida, E., Piazza, S., Collavin, L., Brancolini, C., Schneider, C., Del Sal, G. (2004). The Transcriptional Repressor hDaxx Potentiates p53-dependent Apoptosis. J. Biol. Chem. 279: 48013-48023 [Abstract] [Full Text]
Curtin, J. F., Cotter, T. G. (2004). JNK Regulates HIPK3 Expression and Promotes Resistance to Fas-mediated Apoptosis in DU 145 Prostate Carcinoma Cells. J. Biol. Chem. 279: 17090-17100 [Abstract] [Full Text]
Boellmann, F., Guettouche, T., Guo, Y., Fenna, M., Mnayer, L., Voellmy, R. (2004). DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc. Natl. Acad. Sci. USA 101: 4100-4105 [Abstract] [Full Text]
Moller, A., Sirma, H., Hofmann, T. G., Rueffer, S., Klimczak, E., Droge, W., Will, H., Schmitz, M. L. (2003). PML Is Required for Homeodomain-interacting Protein Kinase 2 (HIPK2)-mediated p53 Phosphorylation and Cell Cycle Arrest but Is Dispensable for the Formation of HIPK Domains. Cancer Res. 63: 4310-4314 [Abstract] [Full Text]
Beisner, D. R., Chu, I. H., Arechiga, A. F., Hedrick, S. M., Walsh, C. M. (2003). The Requirements for Fas-Associated Death Domain Signaling in Mature T Cell Activation and Survival. J. Immunol. 171: 247-256 [Abstract] [Full Text]
Screaton, R. A., Kiessling, S., Sansom, O. J., Millar, C. B., Maddison, K., Bird, A., Clarke, A. R., Frisch, S. M. (2003). Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis. Proc. Natl. Acad. Sci. USA 100: 5211-5216 [Abstract] [Full Text]
Ecsedy, J. A., Michaelson, J. S., Leder, P. (2003). Homeodomain-Interacting Protein Kinase 1 Modulates Daxx Localization, Phosphorylation, and Transcriptional Activity. Mol. Cell. Biol. 23: 950-960 [Abstract] [Full Text]
D'Alessandro, M., Russell, D., Morley, S. M., Davies, A. M., Lane, E. B. (2002). Keratin mutations of epidermolysis bullosa simplex alter the kinetics of stress response to osmotic shock. J. Cell Sci. 115: 4341-4351 [Abstract] [Full Text]
Morgan, M., Thorburn, J., Pandolfi, P. P., Thorburn, A. (2002). Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. JCB 157: 975-984 [Abstract] [Full Text]
Wang, G.-Q., Gastman, B. R., Wieckowski, E., Goldstein, L. A., Rabinovitz, A., Yin, X.-M., Rabinowich, H. (2001). Apoptosis-resistant Mitochondria in T Cells Selected for Resistance to Fas Signaling. J. Biol. Chem. 276: 3610-3619 [Abstract] [Full Text]