Mast Cells Control Neutrophil Recruitment during T Cell-mediated Delayed-type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

doi:10.1084/jem.192.10.1441

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Published online 13 November 2000.

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© The Rockefeller University Press, 0022-1007/2000/11/1441/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 10, November 20, 2000 1441-1452

Original Article

Mast Cells Control Neutrophil Recruitment during T Cell–mediated Delayed-type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

Tilo Biedermann^a, Manfred Kneilling^a, Reinhard Mailhammer^b, Konrad Maier^c, Christian A. Sander^a, George Kollias^d, Steven L. Kunkel^e, Lothar Hültner^b, and Martin Röcken^a
^a Department of Dermatology and Allergology, Ludwig-Maximilians-University Munich, 80337 Munich, Germany
^b Institute of Clinical Molecular Biology and Tumor Genetics, 81377 Munich, Germany
^c Institute of Inhalation Biology, GSF–National Research Center for Environment and Health, 80807 Munich, Germany
^d Hellenic Pasteur Institute, 11521 Athens, Greece
^e Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109

Correspondence to: Martin Röcken, Department of Dermatology and Allergology, Ludwig-Maximilians-University Munich, Frauenlobstr. 9-11, 80337 Munich, Germany. Tel:49-89-5160-6205 Fax:49-89-5160-6206

Polymorphonuclear leukocytes (PMNs) characterize the pathologyof T cell–mediated autoimmune diseases and delayed-typehypersensitivity reactions (DTHRs) in the skin, joints, andgut, but are absent in T cell–mediated autoimmune diseasesof the brain or pancreas. All of these reactions are mediatedby interferon ${gamma}$ –producing type 1 T cells and produce asimilar pattern of cytokines. Thus, the cells and mediatorsresponsible for the PMN recruitment into skin, joints, or gutduring DTHRs remain unknown. Analyzing hapten-induced DTHRsof the skin, we found that mast cells determine the T cell–dependentPMN recruitment through two mediators, tumor necrosis factor(TNF) and the CXC chemokine macrophage inflammatory protein2 (MIP-2), the functional analogue of human interleukin 8. ExtractableMIP-2 protein was abundant during DTHRs in and around mast cellsof wild-type (WT) mice but absent in mast cell–deficientWBB6F₁-Kit^W/Kit^W-^v (Kit^W/Kit^W^-v) mice. T cell–dependentPMN recruitment was reduced >60% by anti–MIP-2 antibodiesand >80% in mast cell–deficient Kit^W/Kit^W^-v mice. Mastcells from WT mice efficiently restored DTHRs and MIP-2–dependentPMN recruitment in Kit^W/Kit^W-^v mice, whereas mast cells fromTNF^-/- mice did not. Thus, mast cell–derived TNF and MIP-2ultimately determine the pattern of infiltrating cells duringT cell–mediated DTHRs.

Key Words: chemokines, inflammation, type 1 T cells, cytokines, autoimmunedisease

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