Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis

doi:10.1084/jem.191.6.1063

Published online 20 March 2000.

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© The Rockefeller University Press, 0022-1007/2000/3/1063/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 6, March 20, 2000 1063-1068

Brief Definitive Report

Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis

Peter E. Kima^a,d, Stephanie L. Constant^b, Lynn Hannum^b, Maria Colmenares^d, Karen S. Lee^b, Ann M. Haberman^c, Mark J. Shlomchik^b,c, and Diane McMahon-Pratt^d
^a Division of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06520-8034
^b Division of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8034
^c Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8034
^d Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520-8034

Correspondence to: Diane McMahon-Pratt, Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St., LEPH 715, P.O. Box 208034, New Haven, CT 06520-8034. Tel:203-785-4481 Fax:203-737-2921 E-mail:diane.mcmahon-pratt{at}yale.edu.

Released online: 20 March 2000

We show here that maintenance of Leishmania infections withLeishmania mexicana complex parasites (Leishmania amazonensisand Leishmania pifanoi) is impaired in the absence of circulatingantibody. In these studies, we used mice genetically alteredto contain no circulating antibody, with and without functionalB cells. This experimental design allowed us to rule out a criticalrole for B cell antigen presentation in Leishmania pathogenesis.In addition, we show that mice lacking the common ${gamma}$ chain ofFc receptors (Fc ${gamma}$ RI, Fc ${epsilon}$ RI, and Fc ${gamma}$ RIII) are similarly refractoryto infection with these parasites. These observations establisha critical role for antibody in the pathogenesis associatedwith infection by members of the L. mexicana complex.

Key Words: Leishmania, Fc receptor , pathogenesis , antigen presentation, infection

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