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Brief Definitive Report |
Correspondence to: Tasuku Honjo, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-ku, Kyoto 606-8501, Japan. Tel:81-75-753-4371 Fax:81-75-753-4388 E-mail:honjo{at}mfour.med.kyoto-u.ac.jp.
Released online: 6 March 2000
/ß (H-Y and 2C) transgenic mice. In these TCR transgenic lines, PD-1 expression in the thymus was variably augmented, but as in the normal mice, confined largely to the CD4-CD8- thymocytes. The transgenic mice crossed with PD-1-/- mice in the neutral genetic backgrounds exhibited selective increase in the CD4+CD8+ (DP) population with little effect on other thymocytes subsets. Similarly, the absence of PD-1 facilitated expansion of DP thymocytes in recombination activating gene (RAG)-2-/- mice by anti-CD3
antibody injection. On the other hand, H-Y or 2C transgenic PD-1-/- mice with the positively selecting background showed significantly reduced efficiency for the generation of CD8+ single positive cells bearing the transgenic TCR-/ß in spite of the increased DP population. These results collectively indicate that PD-1 negatively regulates the ß selection and modulates the positive selection, and suggest that PD-1 deficiency may lead to the significant alteration of mature T cell repertoire.
Key Words: immunoreceptor tyrosine-based inhibitory motif, knock-out mice, positive selection, T cell receptor transgenic mice, RAG-2–deficient mice
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