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Lineage-restricted Function of Nuclear Factor B–inducing Kinase (NIK) in Transducing Signals Via CD40

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor B (NF-B)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-B activation via CD40.

Key Words: CD40 signaling, nuclear factor B–inducing kinase, dendritic cell, nuclear factor B activation, alymphoplasia mice

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