The Reduced Expression of 6Ckine in the plt Mouse Results from the Deletion of One of Two 6Ckine Genes

Correspondence to: Sergio A. Lira, Dept. of Immunology, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033. Tel:908-740-3088 Fax:908-740-3084 E-mail:sergio.lira{at}spcorp.com.

6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of 6Ckine expression in lymphoid organs is a prominent characteristic of mice homozygous for the paucity of lymph node T cell (plt) mutation. These mice show reduced numbers of T cells in lymph nodes, Peyer's patches, and the white pulp of the spleen. The genetic reason for the lack of 6Ckine expression in the plt mouse, however, has remained unknown. Here we demonstrate that mouse 6Ckine is encoded by two genes, one of which is expressed in lymphoid organs and is deleted in plt mice. A second 6Ckine gene is intact and expressed in the plt mouse.

Key Words: chemokines, cell trafficking, leukocyte chemotaxis, T lymphocytes, mutation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Wiede, F., Roomberg, A., Cretney, E., Lechner, A., Fromm, P., Wren, L., Smyth, M. J., Korner, H. (2009). Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice. J. Leukoc. Biol. 85: 108-116 [Abstract] [Full Text]  
• Britschgi, M. R., Link, A., Lissandrin, T. K. A., Luther, S. A. (2008). Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo. J. Immunol. 181: 7681-7688 [Abstract] [Full Text]  
• Manfredi, A. A., Capobianco, A., Esposito, A., De Cobelli, F., Canu, T., Monno, A., Raucci, A., Sanvito, F., Doglioni, C., Nawroth, P. P., Bierhaus, A., Bianchi, M. E., Rovere-Querini, P., Del Maschio, A. (2008). Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes. J. Immunol. 180: 2270-2275 [Abstract] [Full Text]  
• Zhu, M., Chin, R. K., Tumanov, A. V., Liu, X., Fu, Y.-X. (2007). Lymphotoxin Receptor Is Required for the Migration and Selection of Autoreactive T Cells in Thymic Medulla. J. Immunol. 179: 8069-8075 [Abstract] [Full Text]  
• Davalos-Misslitz, A. C. M., Worbs, T., Willenzon, S., Bernhardt, G., Forster, R. (2007). Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood 110: 4351-4359 [Abstract] [Full Text]  
• Levavasseur, E., Metharom, P., Dorban, G., Nakano, H., Kakiuchi, T., Carnaud, C., Sarradin, P., Aucouturier, P. (2007). Experimental scrapie in 'plt' mice: an assessment of the role of dendritic-cell migration in the pathogenesis of prion diseases. J. Gen. Virol. 88: 2353-2360 [Abstract] [Full Text]  
• Schneider, M. A., Meingassner, J. G., Lipp, M., Moore, H. D., Rot, A. (2007). CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. JEM 204: 735-745 [Abstract] [Full Text]  
• Okada, T., Cyster, J. G. (2007). CC Chemokine Receptor 7 Contributes to Gi-Dependent T Cell Motility in the Lymph Node. J. Immunol. 178: 2973-2978 [Abstract] [Full Text]  
• Yasuda, T., Kuwabara, T., Nakano, H., Aritomi, K., Onodera, T., Lipp, M., Takahama, Y., Kakiuchi, T. (2007). Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109: 449-456 [Abstract] [Full Text]  
• Otero, C., Groettrup, M., Legler, D. F. (2006). Opposite Fate of Endocytosed CCR7 and Its Ligands: Recycling versus Degradation. J. Immunol. 177: 2314-2323 [Abstract] [Full Text]  
• Jakubzick, C., Tacke, F., Llodra, J., van Rooijen, N., Randolph, G. J. (2006). Modulation of Dendritic Cell Trafficking to and from the Airways. J. Immunol. 176: 3578-3584 [Abstract] [Full Text]  
• Middel, P, Raddatz, D, Gunawan, B, Haller, F, Radzun, H-J (2006). Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism. Gut 55: 220-227 [Abstract] [Full Text]  
• Legler, D. F., Krause, P., Scandella, E., Singer, E., Groettrup, M. (2006). Prostaglandin E2 Is Generally Required for Human Dendritic Cell Migration and Exerts Its Effect via EP2 and EP4 Receptors. J. Immunol. 176: 966-973 [Abstract] [Full Text]  
• Wang, L., Han, R., Lee, I., Hancock, A. S., Xiong, G., Gunn, M. D., Hancock, W. W. (2005). Permanent Survival of Fully MHC-Mismatched Islet Allografts by Targeting a Single Chemokine Receptor Pathway. J. Immunol. 175: 6311-6318 [Abstract] [Full Text]  
• Wang, Y.-G., Kim, K. D., Wang, J., Yu, P., Fu, Y.-X. (2005). Stimulating Lymphotoxin {beta} Receptor on the Dendritic Cells Is Critical for Their Homeostasis and Expansion. J. Immunol. 175: 6997-7002 [Abstract] [Full Text]  
• Kaiser, A., Donnadieu, E., Abastado, J.-P., Trautmann, A., Nardin, A. (2005). CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen. J. Immunol. 175: 2349-2356 [Abstract] [Full Text]  
• Barbee, S. D., Alberola-Ila, J. (2005). Phosphatidylinositol 3-Kinase Regulates Thymic Exit. J. Immunol. 174: 1230-1238 [Abstract] [Full Text]  
• Qu, C., Edwards, E. W., Tacke, F., Angeli, V., Llodra, J., Sanchez-Schmitz, G., Garin, A., Haque, N. S., Peters, W., van Rooijen, N., Sanchez-Torres, C., Bromberg, J., Charo, I. F., Jung, S., Lira, S. A., Randolph, G. J. (2004). Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes. JEM 200: 1231-1241 [Abstract] [Full Text]  
• Martin, A. P., Coronel, E. C., Sano, G.-i., Chen, S.-C., Vassileva, G., Canasto-Chibuque, C., Sedgwick, J. D., Frenette, P. S., Lipp, M., Furtado, G. C., Lira, S. A. (2004). A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the CC Chemokine CCL21. J. Immunol. 173: 4791-4798 [Abstract] [Full Text]  
• Hopken, U. E., Achtman, A. H., Kruger, K., Lipp, M. (2004). Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens. J. Leukoc. Biol. 76: 709-718 [Abstract] [Full Text]  
• Misslitz, A., Pabst, O., Hintzen, G., Ohl, L., Kremmer, E., Petrie, H. T., Forster, R. (2004). Thymic T Cell Development and Progenitor Localization Depend on CCR7. JEM 200: 481-491 [Abstract] [Full Text]  
• Scimone, M. L., Felbinger, T. W., Mazo, I. B., Stein, J. V., von Andrian, U. H., Weninger, W. (2004). CXCL12 Mediates CCR7-independent Homing of Central Memory Cells, But Not Naive T Cells, in Peripheral Lymph Nodes. JEM 199: 1113-1120 [Abstract] [Full Text]  
• Kwan, J., Killeen, N. (2004). CCR7 Directs the Migration of Thymocytes into the Thymic Medulla. J. Immunol. 172: 3999-4007 [Abstract] [Full Text]  
• Kashiwazaki, M., Tanaka, T., Kanda, H., Ebisuno, Y., Izawa, D., Fukuma, N., Akimitsu, N., Sekimizu, K., Monden, M., Miyasaka, M. (2003). A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions. Int Immunol 15: 1219-1227 [Abstract] [Full Text]  
• Luther, S. A., Ansel, K. M., Cyster, J. G. (2003). Overlapping Roles of CXCL13, Interleukin 7 Receptor {alpha}, and CCR7 Ligands in Lymph Node Development. JEM 197: 1191-1198 [Abstract] [Full Text]  
• Jensen, K. K., Chen, S.-C., Hipkin, R. W., Wiekowski, M. T., Schwarz, M. A., Chou, C.-C., Simas, J. P., Alcami, A., Lira, S. A. (2002). Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68. J. Virol. 77: 624-630 [Abstract] [Full Text]  
• Okada, T., Ngo, V. N., Ekland, E. H., Forster, R., Lipp, M., Littman, D. R., Cyster, J. G. (2002). Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches. JEM 196: 65-75 [Abstract] [Full Text]  
• Luther, S. A., Bidgol, A., Hargreaves, D. C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J. G. (2002). Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis. J. Immunol. 169: 424-433 [Abstract] [Full Text]  
• Junt, T., Nakano, H., Dumrese, T., Kakiuchi, T., Odermatt, B., Zinkernagel, R. M., Hengartner, H., Ludewig, B. (2002). Antiviral Immune Responses in the Absence of Organized Lymphoid T Cell Zones in plt/plt Mice. J. Immunol. 168: 6032-6040 [Abstract] [Full Text]  
• Wright, N., Hidalgo, A., Rodriguez-Frade, J. M., Soriano, S. F., Mellado, M., Parmo-Cabanas, M., Briskin, M. J., Teixido, J. (2002). The Chemokine Stromal Cell-Derived Factor-1{alpha} Modulates {alpha}4{beta}7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin. J. Immunol. 168: 5268-5277 [Abstract] [Full Text]  
• Rappert, A., Biber, K., Nolte, C., Lipp, M., Schubel, A., Lu, B., Gerard, N. P., Gerard, C., Boddeke, H. W. G. M., Kettenmann, H. (2002). Secondary Lymphoid Tissue Chemokine (CCL21) Activates CXCR3 to Trigger a Cl- Current and Chemotaxis in Murine Microglia. J. Immunol. 168: 3221-3226 [Abstract] [Full Text]  
• Grant, A. J., Goddard, S., Ahmed-Choudhury, J., Reynolds, G., Jackson, D. G., Briskin, M., Wu, L., Hubscher, S. G., Adams, D. H. (2002). Hepatic Expression of Secondary Lymphoid Chemokine (CCL21) Promotes the Development of Portal-Associated Lymphoid Tissue in Chronic Inflammatory Liver Disease. Am. J. Pathol. 160: 1445-1455 [Abstract] [Full Text]  
• Chen, S.-C., Vassileva, G., Kinsley, D., Holzmann, S., Manfra, D., Wiekowski, M. T., Romani, N., Lira, S. A. (2002). Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice. J. Immunol. 168: 1001-1008 [Abstract] [Full Text]  
• Chen, S.-C., Leach, M. W., Chen, Y., Cai, X.-Y., Sullivan, L., Wiekowski, M., Dovey-Hartman, B. J., Zlotnik, A., Lira, S. A. (2002). Central Nervous System Inflammation and Neurological Disease in Transgenic Mice Expressing the CC Chemokine CCL21 in Oligodendrocytes. J. Immunol. 168: 1009-1017 [Abstract] [Full Text]  
• Ploix, C., Lo, D., Carson, M. J. (2001). A Ligand for the Chemokine Receptor CCR7 Can Influence the Homeostatic Proliferation of CD4 T Cells and Progression of Autoimmunity. J. Immunol. 167: 6724-6730 [Abstract] [Full Text]  
• Christopherson, K. W. II, Campbell, J. J., Hromas, R. A. (2001). Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. Blood 98: 3562-3568 [Abstract] [Full Text]  
• Weninger, W., Crowley, M. A., Manjunath, N., von Andrian, U. H. (2001). Migratory Properties of Naive, Effector, and Memory CD8+ T Cells. JEM 194: 953-966 [Abstract] [Full Text]  
• Christopherson, K. II, Hromas, R. (2001). Chemokine Regulation of Normal and Pathologic Immune Responses. Stem Cells 19: 388-396 [Abstract] [Full Text]  
• Kellermann, S.-A., McEvoy, L. M. (2001). The Peyer's Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli. J. Immunol. 167: 682-690 [Abstract] [Full Text]  
• Takemura, S., Braun, A., Crowson, C., Kurtin, P. J., Cofield, R. H., O'Fallon, W. M., Goronzy, J. J., Weyand, C. M. (2001). Lymphoid Neogenesis in Rheumatoid Synovitis. J. Immunol. 167: 1072-1080 [Abstract] [Full Text]  
• Rennert, P. D., Hochman, P. S., Flavell, R. A., Chaplin, D. D., Jayaraman, S., Browning, J. L., Fu, Y.-X. (2001). Essential Role of Lymph Nodes in Contact Hypersensitivity Revealed in Lymphotoxin-{alpha}-deficient Mice. JEM 193: 1227-1238 [Abstract] [Full Text]  
• Baekkevold, E. S., Yamanaka, T., Palframan, R. T., Carlsen, H. S., Reinholt, F. P., von Andrian, U. H., Brandtzaeg, P., Haraldsen, G. (2001). The CCR7 Ligand ELC (CCL19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment. JEM 193: 1105-1112 [Abstract] [Full Text]  
• Hjelmström, P. (2001). Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines. J. Leukoc. Biol. 69: 331-339 [Abstract] [Full Text]  
• Itakura, M., Tokuda, A., Kimura, H., Nagai, S., Yoneyama, H., Onai, N., Ishikawa, S., Kuriyama, T., Matsushima, K. (2001). Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates Propionibacterium acnes-Induced Acute Lung Inflammation. J. Immunol. 166: 2071-2079 [Abstract] [Full Text]  
• Mori, S., Nakano, H., Aritomi, K., Wang, C.-R., Gunn, M. D., Kakiuchi, T. (2001). Mice Lacking Expression of the Chemokines CCL21-Ser and CCL19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses. JEM 193: 207-218 [Abstract] [Full Text]  
• Nakano, H., Gunn, M. D. (2001). Gene Duplications at the Chemokine Locus on Mouse Chromosome 4: Multiple Strain-Specific Haplotypes and the Deletion of Secondary Lymphoid-Organ Chemokine and EBI-1 Ligand Chemokine Genes in the plt Mutation. J. Immunol. 166: 361-369 [Abstract] [Full Text]  
• Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., Forster, R. (2000). Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production. JEM 192: 1545-1552 [Abstract] [Full Text]  
• Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P., Moser, B. (2000). CXC Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function. JEM 192: 1553-1562 [Abstract] [Full Text]  
• Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G., Cyster, J. G. (2000). Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97: 12694-12699 [Abstract] [Full Text]  
• Pan, J., Kunkel, E. J., Gosslar, U., Lazarus, N., Langdon, P., Broadwell, K., Vierra, M. A., Genovese, M. C., Butcher, E. C., Soler, D. (2000). Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues. J. Immunol. 165: 2943-2949 [Abstract] [Full Text]  
• Stein, J. V., Rot, A., Luo, Y., Narasimhaswamy, M., Nakano, H., Gunn, M. D., Matsuzawa, A., Quackenbush, E. J., Dorf, M. E., von Andrian, U. H. (2000). The CC Chemokine Thymus-derived Chemotactic Agent 4 (TCA-4, Secondary Lymphoid Tissue Chemokine, 6Ckine, Exodus-2) Triggers Lymphocyte Function-associated Antigen 1-mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules. JEM 191: 61-76 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS