J. Exp. Med., Volume 187, Number 8, April 20, 1998 1355-1360

BRIEF DEFINITIVE REPORT:
Requirement of SH2-containing Protein Tyrosine Phosphatases SHP-1 and SHP-2 for Paired Immunoglobulin-like Receptor B (PIR-B)-mediated Inhibitory Signal

By Akito Maeda,^* Mari Kurosaki,^* Masao Ono,^§ Toshiyuki Takai,^§ and Tomohiro Kurosaki^*

From the ^* Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570, Japan; the  Department of Molecular Embryology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4-1, Sendai 980-77, Japan; and ^§ Core Research for Evolution Science and Technology, Japan Science and Technology Corporation, Japan

Paired immunoglobulin-like receptor B (PIR-B) (p91) molecule has been proposed to function as an inhibitory receptor in B cells and myeloid lineage cells. We demonstrate here that the cytoplasmic region of PIR-B is capable of inhibiting B cell activation. Mutational analysis of five cytoplasmic tyrosines indicate that tyrosine 771 in the motif VxYxxL plays the most crucial role in mediating the inhibitory signal. PIR-B-mediated inhibition was markedly reduced in the SH2-containing protein tyrosine phosphatases SHP-1 and SHP-2 double-deficient DT40 B cells, whereas this inhibition was unaffected in the inositol polyphosphate 5'-phosphatase SHIP-deficient cells. These data demonstrate that PIR-B can negatively regulate B cell receptor activation and that this PIR-B-mediated inhibition requires redundant functions of SHP-1 and SHP-2.

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