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J. Exp. Med.,
Volume 187, Number 2, January 19, 1998 197-204
By
From * The Center for Blood Research, the Peripheral lymph nodes (PLN) are critical for immunologic memory formation in response to
antigens that penetrate the skin. Blood-borne lymphocytes first encounter such antigens after
they home to PLN through a multi-step adhesion process that is normally initiated by L-selectin (CD62L) in high endothelial venules (HEV). Since naive T cells can not enter PLN normally in L-selectin-deficient mice, a delayed type hypersensitivity response to cutaneously applied antigen cannot be mounted. In this study, we report that the administration of activated
platelets into the systemic circulation of L-selectin knockout mice restores lymphocyte trafficking to PLN, and reconstitutes T cell-mediated immunity in response to a cutaneous antigen.
These effects required platelet-expressed P-selectin that allows activated platelets to transiently
form a bridge between lymphocytes and HEV, thereby enabling lymphocytes to undergo subsequent Department of Cardiology, and the § Department of
Pathology, Harvard Medical School, Boston, Massachusetts 02115; the Division of Newborn
Medicine, Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts
02111; and the ¶ Department of Pathology, University of Texas Southwestern Medical Center, Dallas,
Texas 75235-9069
2 integrin-dependent firm adhesion. These profound effects of platelet-mediated
cell-cell interactions on lymphocyte trafficking and formation of immunologic memory may impact on a variety of autoimmune and inflammatory conditions.
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