An Alternate Pathway for T Cell Development Supported by the Bone Marrow Microenvironment: Recapitulation of Thymic Maturation

doi:10.1084/jem.187.11.1813

3rd Skeletal Biology and Medicine Symposium

This Article

	Full Text
	Full Text (PDF, 196K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by García-Ojeda, M. E.
	Articles by Strober, S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by García-Ojeda, M. E.
	Articles by Strober, S.


Social Bookmarking

	What's this?

J. Exp. Med., Volume 187, Number 11, June 1, 1998 1813-1823

An Alternate Pathway for T Cell Development Supported by the Bone Marrow Microenvironment: Recapitulation of Thymic Maturation

By Marcos E. García-Ojeda,^* Sussan Dejbakhsh-Jones,^* Irving L. Weissman, and Samuel Strober^*

From the ^* Division of Immunology and Rheumatology, Department of Medicine, and the Department of Pathology, Stanford University School of Medicine, Stanford, California 94305

In the principal pathway of $alpha$ / $beta$ T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceedthrough several well-characterized developmental stages into matureCD4⁺ and CD8⁺ T cells. This study demonstrates an alternative pathway in whichthe bone marrow microenvironment also supports the differentiationof T cell precursors into CD4⁺ and CD8⁺ T cells. The marrow pathway recapitulates developmental stagesof thymic maturation including a CD4⁺CD8⁺ intermediary cell and positive and negative selection, and isstrongly inhibited by the presence of mature T cells. The contributionof the marrow pathway in vivo requires further study in mice withnormal and deficient thymic or immune function.

Key words: extrathymic; bone marrow; T cell; development; thymus

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Gautreau, L., Arcangeli, M.-L., Pasqualetto, V., Joret, A.-M., Garcia-Cordier, C., Megret, J., Schneider, E., Ezine, S. (2007). Identification of an IL-7-Dependent Pre-T Committed Population in the Spleen. J. Immunol. 179: 2925-2935 [Abstract] [Full Text]
Garcia-Ojeda, M. E., Dejbakhsh-Jones, S., Chatterjea-Matthes, D., Mukhopadhyay, A., BitMansour, A., Weissman, I. L., Brown, J. M. Y., Strober, S. (2005). Stepwise Development of Committed Progenitors in the Bone Marrow That Generate Functional T Cells in the Absence of the Thymus. J. Immunol. 175: 4363-4373 [Abstract] [Full Text]
Samira, S., Ferrand, C., Peled, A., Nagler, A., Tovbin, Y., Ben-Hur, H., Taylor, N., Globerson, A., Lapidot, T. (2004). Tumor Necrosis Factor Promotes Human T-Cell Development in Nonobese Diabetic/Severe Combined Immunodeficient Mice. Stem Cells 22: 1085-1100 [Abstract] [Full Text]
Gniadecki, R. (2004). Neoplastic Stem Cells in Cutaneous Lymphomas: Evidence and Clinical Implications. Arch Dermatol 140: 1156-1160 [Full Text]
Klein, F., Feldhahn, N., Lee, S., Wang, H., Ciuffi, F., von Elstermann, M., Toribio, M. L., Sauer, H., Wartenberg, M., Barath, V. S., Kronke, M., Wernet, P., Rowley, J. D., Muschen, M. (2003). T lymphoid differentiation in human bone marrow. Proc. Natl. Acad. Sci. USA 100: 6747-6752 [Abstract] [Full Text]
Williams, M. A., Adams, A. B., Walsh, M. B., Shirasugi, N., Onami, T. M., Pearson, T. C., Ahmed, R., Larsen, C. P. (2003). Primary and Secondary Immunocompetence in Mixed Allogeneic Chimeras. J. Immunol. 170: 2382-2389 [Abstract] [Full Text]
Zeng, D., Hoffmann, P., Lan, F., Huie, P., Higgins, J., Strober, S. (2002). Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation. Blood 99: 1449-1457 [Abstract] [Full Text]
Dejbakhsh-Jones, S., Garcia-Ojeda, M. E., Chatterjea-Matthes, D., Zeng, D., Strober, S. (2001). Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway. Proc. Natl. Acad. Sci. USA 10.1073/pnas.131559798v1 [Abstract] [Full Text]
Boileau, C., Houde, M., Dulude, G., Clegg, C. H., Perreault, C. (2000). Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M. J. Immunol. 164: 5713-5720 [Abstract] [Full Text]
Zeng, D., Lee, M.-K., Tung, J., Brendolan, A., Strober, S. (2000). Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice. J. Immunol. 164: 5000-5004 [Abstract] [Full Text]
Akashi, K., Richie, L. I., Miyamoto, T., Carr, W. H., Weissman, I. L. (2000). B Lymphopoiesis in the Thymus. J. Immunol. 164: 5221-5226 [Abstract] [Full Text]
Dejbakhsh-Jones, S., Strober, S. (1999). Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow. Proc. Natl. Acad. Sci. USA 96: 14493-14498 [Abstract] [Full Text]
Zeng, D., Gazit, G., Dejbakhsh-Jones, S., Balk, S. P., Snapper, S., Taniguchi, M., Strober, S. (1999). Heterogeneity of NK1.1+ T Cells in the Bone Marrow: Divergence from the Thymus. J. Immunol. 163: 5338-5345 [Abstract] [Full Text]
Ziegler, B. L., Valtieri, M., Porada, G. A., Maria, R. D., Müller, R., Masella, B., Gabbianelli, M., Casella, I., Pelosi, E., Bock, T., Zanjani, E. D., Peschle, C. (1999). KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells. Science 285: 1553-1558 [Abstract] [Full Text]
Hebib, N. C., Deas, O., Rouleau, M., Durrbach, A., Charpentier, B., Beaujean, F., Vernant, J.-P., Senik, A. (1999). Peripheral Blood T Cells Generated After Allogeneic Bone Marrow Transplantation: Lower Levels of Bcl-2 Protein and Enhanced Sensitivity to Spontaneous and CD95-Mediated Apoptosis In Vitro. Abrogation of the Apoptotic Phenotype Coincides With the Recovery of Normal Naive/Primed T-Cell Profiles. Blood 94: 1803-1813 [Abstract] [Full Text]
Poulin, J.-F., Viswanathan, M. N., Harris, J. M., Komanduri, K. V., Wieder, E., Ringuette, N., Jenkins, M., McCune, J. M., Sekaly, R.-P. (1999). Direct Evidence for Thymic Function in Adult Humans. JEM 190: 479-486 [Abstract] [Full Text]
Brochu, S., Rioux-Masse, B., Roy, J., Roy, D.-C., Perreault, C. (1999). Massive Activation-Induced Cell Death of Alloreactive T Cells With Apoptosis of Bystander Postthymic T Cells Prevents Immune Reconstitution in Mice With Graft-Versus-Host Disease. Blood 94: 390-400 [Abstract] [Full Text]
Robin, C., Pflumio, F., Vainchenker, W., Coulombel, L. (1999). Identification of Lymphomyeloid Primitive Progenitor Cells in Fresh Human Cord Blood and in the Marrow of Nonobese Diabetic-Severe Combined Immunodeficient (NOD-SCID) Mice Transplanted with Human CD34+ Cord Blood Cells. JEM 189: 1601-1610 [Abstract] [Full Text]
Dulude, G., Roy, D.-C., Perreault, C. (1999). The Effect of Graft-versus-Host Disease on T Cell Production and Homeostasis. JEM 189: 1329-1342 [Abstract] [Full Text]
Zeng, D., Lewis, D., Dejbakhsh-Jones, S., Lan, F., Garcia-Ojeda, M., Sibley, R., Strober, S. (1999). Bone Marrow NK1.1- and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host Disease. JEM 189: 1073-1081 [Abstract] [Full Text]
AKASHI, K., KONDO, M., CHESHIER, S., SHIZURU, J., GANDY, K., DOMEN, J., MEBIUS, R., TRAVER, D., WEISSMAN, I.L. (1999). Lymphoid Development from Stem Cells and the Common Lymphocyte Progenitors. Cold Spring Harb Symp Quant Biol 64: 1-12 [Abstract]
Dejbakhsh-Jones, S., Garcia-Ojeda, M. E., Chatterjea-Matthes, D., Zeng, D., Strober, S. (2001). Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway. Proc. Natl. Acad. Sci. USA 98: 7455-7460 [Abstract] [Full Text]