J. Exp. Med.
Volume 186, Number 1, July 7, 1997 165-170

BRIEF DEFINITIVE REPORT:
Identification of CCR8: A Human Monocyte and Thymus Receptor for the CC Chemokine I-309

By H. Lee Tiffany,^* Laura L. Lautens, Ji-Liang Gao,^* James Pease,^* Massimo Locati,^* Christophe Combadiere,^* William Modi,^¶ Tom I. Bonner,^§ and Philip M. Murphy^*

From the ^* Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, and the  Laboratory of Cell Biology and ^§ Section on Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892;  the Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom; the ^¶ Biological Carcinogenesis and Development Program, Program Resources, Incorporated/Dyncorp, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201

The human CC chemokine I-309 is a potent monocyte chemoattractant and inhibits apoptosis in thymic cell lines. Here, we identify a specific human I-309 receptor, and name it CCR8 according to an accepted nomenclature system. The receptor has seven predicted transmembrane domains, is expressed constitutively in monocytes and thymus, and is encoded by a previously reported gene of previously unknown function named, alternatively, CY6, TER1, and CKR-L1. After transfection with the CY6 open reading frame, a mouse pre-B cell line exhibited calcium flux and chemotaxis in response to I-309 (EC₅₀ = 2 nM for each), whereas 20 other chemokines were inactive. Signaling was sensitive to pertussis toxin, suggesting coupling to a G_i-type G protein. These properties parallel those of endogenous I-309 receptors expressed in an HL-60 clone 15 cell line model. The apparent monogamous relationship between I-309 and CCR8 is unusual among known CC chemokines and known CC chemokine receptors. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Hintzen, C., Haan, C., Tuckermann, J. P., Heinrich, P. C., Hermanns, H. M. (2008). Oncostatin M-Induced and Constitutive Activation of the JAK2/STAT5/CIS Pathway Suppresses CCL1, but Not CCL7 and CCL8, Chemokine Expression. J. Immunol. 181: 7341-7349 [Abstract] [Full Text]  
• Poh, T. Y., Pease, J., Young, J. R., Bumstead, N., Kaiser, P. (2008). Re-evaluation of Chicken CXCR1 Determines the True Gene Structure: CXCLi1 (K60) AND CXCLi2 (CAF/INTERLEUKIN-8) ARE LIGANDS FOR THIS RECEPTOR. J. Biol. Chem. 283: 16408-16415 [Abstract] [Full Text]  
• Fox, J. M., Najarro, P., Smith, G. L., Struyf, S., Proost, P., Pease, J. E. (2006). Structure/Function Relationships of CCR8 Agonists and Antagonists: AMINO-TERMINAL EXTENSION OF CCL1 BY A SINGLE AMINO ACID GENERATES A PARTIAL AGONIST. J. Biol. Chem. 281: 36652-36661 [Abstract] [Full Text]  
• Soler, D., Chapman, T. R., Poisson, L. R., Wang, L., Cote-Sierra, J., Ryan, M., McDonald, A., Badola, S., Fedyk, E., Coyle, A. J., Hodge, M. R., Kolbeck, R. (2006). CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes. J. Immunol. 177: 6940-6951 [Abstract] [Full Text]  
• Montes-Vizuet, R., Vega-Miranda, A., Valencia-Maqueda, E., Negrete-Garcia, M. C., Velasquez, J. R., Teran, L. M. (2006). CC chemokine ligand 1 is released into the airways of atopic asthmatics. Eur Respir J 28: 59-67 [Abstract] [Full Text]  
• Najarro, P., Gubser, C., Hollinshead, M., Fox, J., Pease, J., Smith, G. L. (2006). Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.. J. Gen. Virol. 87: 809-816 [Abstract] [Full Text]  
• Guessous, F., Marcinkiewicz, M., Polanowska-Grabowska, R., Kongkhum, S., Heatherly, D., Obrig, T., Gear, A. R. L. (2005). Shiga Toxin 2 and Lipopolysaccharide Induce Human Microvascular Endothelial Cells To Release Chemokines and Factors That Stimulate Platelet Function. Infect. Immun. 73: 8306-8316 [Abstract] [Full Text]  
• Hashida, N., Ohguro, N., Nakai, K., Kobashi-Hashida, M., Hashimoto, S.-i., Matsushima, K., Tano, Y. (2005). Microarray Analysis of Cytokine and Chemokine Gene Expression after Prednisolone Treatment in Murine Experimental Autoimmune Uveoretinitis. IOVS 46: 4224-4234 [Abstract] [Full Text]  
• Qu, C., Edwards, E. W., Tacke, F., Angeli, V., Llodra, J., Sanchez-Schmitz, G., Garin, A., Haque, N. S., Peters, W., van Rooijen, N., Sanchez-Torres, C., Bromberg, J., Charo, I. F., Jung, S., Lira, S. A., Randolph, G. J. (2004). Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes. JEM 200: 1231-1241 [Abstract] [Full Text]  
• Ruffini, P. A., Biragyn, A., Coscia, M., Harvey, L. K., Cha, S.-C., Bogen, B., Kwak, L. W. (2004). Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis. J. Leukoc. Biol. 76: 77-85 [Abstract] [Full Text]  
• Schaerli, P., Ebert, L., Willimann, K., Blaser, A., Roos, R. S., Loetscher, P., Moser, B. (2004). A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells. JEM 199: 1265-1275 [Abstract] [Full Text]  
• Gutierrez, J., Kremer, L., Zaballos, A., Goya, I., Martinez-A., C., Marquez, G. (2004). Analysis of Post-translational CCR8 Modifications and Their Influence on Receptor Activity. J. Biol. Chem. 279: 14726-14733 [Abstract] [Full Text]  
• Haque, N. S., Fallon, J. T., Pan, J. J., Taubman, M. B., Harpel, P. C. (2004). Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood 103: 1296-1304 [Abstract] [Full Text]  
• Najarro, P., Lee, H.-J., Fox, J., Pease, J., Smith, G. L. (2003). Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1. J. Gen. Virol. 84: 3325-3336 [Abstract] [Full Text]  
• Ogilvie, P., Paoletti, S., Clark-Lewis, I., Uguccioni, M. (2003). Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Blood 102: 789-794 [Abstract] [Full Text]  
• DeVries, M. E., Cao, H., Wang, J., Xu, L., Kelvin, A. A., Ran, L., Chau, L. A., Madrenas, J., Hegele, R. A., Kelvin, D. J. (2003). Genomic Organization and Evolution of the CX3CR1/CCR8 Chemokine Receptor Locus. J. Biol. Chem. 278: 11985-11994 [Abstract] [Full Text]  
• Goya, I., Villares, R., Zaballos, A., Gutierrez, J., Kremer, L., Gonzalo, J.-A., Varona, R., Carramolino, L., Serrano, A., Pallares, P., Criado, L. M., Kolbeck, R., Torres, M., Coyle, A. J., Gutierrez-Ramos, J.-C., Martinez-A, C., Marquez, G. (2003). Absence of CCR8 Does Not Impair the Response to Ovalbumin-Induced Allergic Airway Disease. J. Immunol. 170: 2138-2146 [Abstract] [Full Text]  
• Trebst, C., Staugaitis, S. M., Kivisakk, P., Mahad, D., Cathcart, M. K., Tucky, B., Wei, T., Rani, M. R. S., Horuk, R., Aldape, K. D., Pardo, C. A., Lucchinetti, C. F., Lassmann, H., Ransohoff, R. M. (2003). CC Chemokine Receptor 8 in the Central Nervous System Is Associated with Phagocytic Macrophages. Am. J. Pathol. 162: 427-438 [Abstract] [Full Text]  
• Spinetti, G., Bernardini, G., Camarda, G., Mangoni, A., Santoni, A., Capogrossi, M. C., Napolitano, M. (2003). The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. J. Leukoc. Biol. 73: 201-207 [Abstract] [Full Text]  
• Chung, C. D., Kuo, F., Kumer, J., Motani, A. S., Lawrence, C. E., Henderson, W. R. Jr., Venkataraman, C. (2003). CCR8 Is Not Essential for the Development of Inflammation in a Mouse Model of Allergic Airway Disease. J. Immunol. 170: 581-587 [Abstract] [Full Text]  
• Murakami, T., Maki, W., Cardones, A. R., Fang, H., Tun Kyi, A., Nestle, F. O., Hwang, S. T. (2002). Expression of CXC Chemokine Receptor-4 Enhances the Pulmonary Metastatic Potential of Murine B16 Melanoma Cells. Cancer Res. 62: 7328-7334 [Abstract] [Full Text]  
• Nakajima, T., Inagaki, N., Tanaka, H., Tanaka, A., Yoshikawa, M., Tamari, M., Hasegawa, K., Matsumoto, K., Tachimoto, H., Ebisawa, M., Tsujimoto, G., Matsuda, H., Nagai, H., Saito, H. (2002). Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison. Blood 100: 3861-3868 [Abstract] [Full Text]  
• Beaulieu, S., Robbiani, D. F., Du, X., Rodrigues, E., Ignatius, R., Wei, Y., Ponath, P., Young, J. W., Pope, M., Steinman, R. M., Mojsov, S. (2002). Expression of a Functional Eotaxin (CC Chemokine Ligand 11) Receptor CCR3 by Human Dendritic Cells. J. Immunol. 169: 2925-2936 [Abstract] [Full Text]  
• Zaitseva, M., Kawamura, T., Loomis, R., Goldstein, H., Blauvelt, A., Golding, H. (2002). Stromal-Derived Factor 1 Expression in the Human Thymus. J. Immunol. 168: 2609-2617 [Abstract] [Full Text]  
• Jopling, L. A., Sabroe, I., Andrew, D. P., Mitchell, T. J., Li, Y., Hodge, M. R., Williams, T. J., Pease, J. E. (2002). The Identification, Characterization, and Distribution of Guinea Pig CCR4 and Epitope Mapping of a Blocking Antibody. J. Biol. Chem. 277: 6864-6873 [Abstract] [Full Text]  
• Liu, C., Okruzhnov, Y., Li, H., Nicholas, J. (2001). Human Herpesvirus 8 (HHV-8)-Encoded Cytokines Induce Expression of and Autocrine Signaling by Vascular Endothelial Growth Factor (VEGF) in HHV-8-Infected Primary-Effusion Lymphoma Cell Lines and Mediate VEGF-Independent Antiapoptotic Effects. J. Virol. 75: 10933-10940 [Abstract] [Full Text]  
• Wiley, H. E., Gonzalez, E. B., Maki, W., Wu, M.-t., Hwang, S. T. (2001). Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma. JNCI J Natl Cancer Inst 93: 1638-1643 [Abstract] [Full Text]  
• Ruckes, T., Saul, D., Van Snick, J., Hermine, O., Grassmann, R. (2001). Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. Blood 98: 1150-1159 [Abstract] [Full Text]  
• Luttichau, H. R., Gerstoft, J., Schwartz, T. W. (2001). MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. J. Leukoc. Biol. 70: 277-282 [Abstract] [Full Text]  
• Fort, M. M., Lesley, R., Davidson, N. J., Menon, S., Brombacher, F., Leach, M. W., Rennick, D. M. (2001). IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis. J. Immunol. 166: 2793-2800 [Abstract] [Full Text]  
• Kremer, L., Carramolino, L., Goya, I., Zaballos, A., Gutierrez, J., del Carmen Moreno-Ortiz, M., Martinez-A., C., Marquez, G. (2001). The Transient Expression of C-C Chemokine Receptor 8 in Thymus Identifies a Thymocyte Subset Committed to Become CD4+ Single-Positive T Cells. J. Immunol. 166: 218-225 [Abstract] [Full Text]  
• Haque, N. S., Fallon, J. T., Taubman, M. B., Harpel, P. C. (2001). The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. Blood 97: 39-45 [Abstract] [Full Text]  
• Bernardini, G., Spinetti, G., Ribatti, D., Camarda, G., Morbidelli, L., Ziche, M., Santoni, A., Capogrossi, M. C., Napolitano, M. (2000). I-309 binds to and activates endothelial cell functions and acts as an angiogenic molecule in vivo. Blood 96: 4039-4045 [Abstract] [Full Text]  
• Xiao, H., Neuveut, C., Tiffany, H. L., Benkirane, M., Rich, E. A., Murphy, P. M., Jeang, K.-T. (2000). Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1. Proc. Natl. Acad. Sci. USA 97: 11466-11471 [Abstract] [Full Text]  
• Haque, N. S., Zhang, X., French, D. L., Li, J., Poon, M., Fallon, J. T., Gabel, B. R., Taubman, M. B., Koschinsky, M., Harpel, P. C. (2000). CC Chemokine I-309 Is the Principal Monocyte Chemoattractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells. Circulation 102: 786-792 [Abstract] [Full Text]  
• Lee, S., Tiffany, H. L., King, L., Murphy, P. M., Golding, H., Zaitseva, M. B. (2000). CCR8 on Human Thymocytes Functions as a Human Immunodeficiency Virus Type 1 Coreceptor. J. Virol. 74: 6946-6952 [Abstract] [Full Text]  
• Murdoch, C., Finn, A. (2000). Chemokine receptors and their role in inflammation and infectious diseases. Blood 95: 3032-3043 [Abstract] [Full Text]  
• Inngjerdingen, M., Damaj, B., Maghazachi, A. A. (2000). Human NK Cells Express CC Chemokine Receptors 4 and 8 and Respond to Thymus and Activation-Regulated Chemokine, Macrophage-Derived Chemokine, and I-309. J. Immunol. 164: 4048-4054 [Abstract] [Full Text]  
• Jarmin, D. I., Rits, M., Bota, D., Gerard, N. P., Graham, G. J., Clark-Lewis, I., Gerard, C. (2000). Cutting Edge: Identification of the Orphan Receptor G-Protein-Coupled Receptor 2 as CCR10, a Specific Receptor for the Chemokine ESkine. J. Immunol. 164: 3460-3464 [Abstract] [Full Text]  
• Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., Power, C. A. (2000). International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors. Pharmacol. Rev. 52: 145-176 [Abstract] [Full Text]  
• Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., Takahashi, T. A. (2000). TGF-{beta}1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors. J. Immunol. 164: 2285-2295 [Abstract] [Full Text]  
• Norment, A. M., Bogatzki, L. Y., Gantner, B. N., Bevan, M. J. (2000). Murine CCR9, a Chemokine Receptor for Thymus-Expressed Chemokine That Is Up-Regulated Following Pre-TCR Signaling. J. Immunol. 164: 639-648 [Abstract] [Full Text]  
• Singh, A., Besson, G., Mobasher, A., Collman, R. G. (1999). Patterns of Chemokine Receptor Fusion Cofactor Utilization by Human Immunodeficiency Virus Type 1 Variants from the Lungs and Blood. J. Virol. 73: 6680-6690 [Abstract] [Full Text]  
• Dairaghi, D. J., Fan, R. A., McMaster, B. E., Hanley, M. R., Schall, T. J. (1999). HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8. AGONIST AND ANTAGONIST PROFILES OF VIRAL CHEMOKINES. J. Biol. Chem. 274: 21569-21574 [Abstract] [Full Text]  
• Endres, M. J., Garlisi, C. G., Xiao, H., Shan, L., Hedrick, J. A. (1999). The Kaposi's Sarcoma-related Herpesvirus (KSHV)-encoded Chemokine vMIP-I is a Specific Agonist for the CC Chemokine Receptor (CCR)8. JEM 189: 1993-1998 [Abstract] [Full Text]  
• Nardelli, B., Tiffany, H. L., Bong, G. W., Yourey, P. A., Morahan, D. K., Li, Y., Murphy, P. M., Alderson, R. F. (1999). Characterization of the Signal Transduction Pathway Activated in Human Monocytes and Dendritic Cells by MPIF-1, a Specific Ligand for CC Chemokine Receptor 1. J. Immunol. 162: 435-444 [Abstract] [Full Text]  
• Pedroza-Martins, L., Gurney, K. B., Torbett, B. E., Uittenbogaart, C. H. (1998). Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level. J. Virol. 72: 9441-9452 [Abstract] [Full Text]  
• Sozzani, S., Luini, W., Bianchi, G., Allavena, P., Wells, T.N.C., Napolitano, M., Bernardini, G., Vecchi, A., D'Ambrosio, D., Mazzeo, D., Sinigaglia, F., Santoni, A., Maggi, E., Romagnani, S., Mantovani, A. (1998). The Viral Chemokine Macrophage Inflammatory Protein-II Is a Selective Th2 Chemoattractant. Blood 92: 4036-4039 [Abstract] [Full Text]  
• D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., Sinigaglia, F. (1998). Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells. J. Immunol. 161: 5111-5115 [Abstract] [Full Text]  
• Combadiere, C., Salzwedel, K., Smith, E. D., Tiffany, H. L., Berger, E. A., Murphy, P. M. (1998). Identification of CX3CR1. A CHEMOTACTIC RECEPTOR FOR THE HUMAN CX3C CHEMOKINE FRACTALKINE AND A FUSION CORECEPTOR FOR HIV-1. J. Biol. Chem. 273: 23799-23804 [Abstract] [Full Text]  
• Pease, J. E., Wang, J., Ponath, P. D., Murphy, P. M. (1998). The N-terminal Extracellular Segments of the Chemokine Receptors CCR1 and CCR3 Are Determinants for MIP-1alpha and Eotaxin Binding, Respectively, but a Second Domain Is Essential for Efficient Receptor Activation. J. Biol. Chem. 273: 19972-19976 [Abstract] [Full Text]  
• Tsou, C.-L., Gladue, R. P., Carroll, L. A., Paradis, T., Boyd, J. G., Nelson, R. T., Neote, K., Charo, I. F. (1998). Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor. JEM 188: 603-608 [Abstract] [Full Text]  
• Zingoni, A., Soto, H., Hedrick, J. A., Stoppacciaro, A., Storlazzi, C. T., Sinigaglia, F., D'Ambrosio, D., O'Garra, A., Robinson, D., Rocchi, M., Santoni, A., Zlotnik, A., Napolitano, M. (1998). Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells. J. Immunol. 161: 547-551 [Abstract] [Full Text]  
• Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G., Neote, K. (1998). Interferon-inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3. JEM 187: 2009-2021 [Abstract] [Full Text]  
• Damon, I., Murphy, P. M., Moss, B. (1998). Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog. Proc. Natl. Acad. Sci. USA 95: 6403-6407 [Abstract] [Full Text]  
• Youn, B.-S., Zhang, S. M., Broxmeyer, H. E., Cooper, S., Antol, K., Fraser, M. Jr, Kwon, B. S. (1998). Characterization of CKbeta 8 and CKbeta 8-1: Two Alternatively Spliced Forms of Human beta -Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1 . Blood 91: 3118-3126 [Abstract] [Full Text]  
• Yoshida, R., Nagira, M., Kitaura, M., Imagawa, N., Imai, T., Yoshie, O. (1998). Secondary Lymphoid-tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7. J. Biol. Chem. 273: 7118-7122 [Abstract] [Full Text]  
• Hayes, I. M., Jordan, N. J., Towers, S., Smith, G., Paterson, J. R., Earnshaw, J. J., Roach, A. G., Westwick, J., Williams, R. J. (1998). Human Vascular Smooth Muscle Cells Express Receptors for CC Chemokines. Arterioscler. Thromb. Vasc. Bio. 18: 397-403 [Abstract] [Full Text]  
• Goya, I., Gutierrez, J., Varona, R., Kremer, L., Zaballos, A., Marquez, G. (1998). Identification of CCR8 as the Specific Receptor for the Human {beta}-Chemokine I-309: Cloning and Molecular Characterization of Murine CCR8 as the Receptor for TCA-3. J. Immunol. 160: 1975-1981 [Abstract] [Full Text]  
• Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W. (1998). Macrophage-derived Chemokine Is a Functional Ligand for the CC Chemokine Receptor 4. J. Biol. Chem. 273: 1764-1768 [Abstract] [Full Text]  
• Horuk, R., Hesselgesser, J., Zhou, Y., Faulds, D., Halks-Miller, M., Harvey, S., Taub, D., Samson, M., Parmentier, M., Rucker, J., Doranz, B. J., Doms, R. W. (1998). The CC Chemokine I-309 Inhibits CCR8-dependent Infection by Diverse HIV-1 Strains. J. Biol. Chem. 273: 386-391 [Abstract] [Full Text]  
• Nibbs, R. J. B., Wylie, S. M., Yang, J., Landau, N. R., Graham, G. J. (1997). Cloning and Characterization of a Novel Promiscuous Human beta -Chemokine Receptor D6. J. Biol. Chem. 272: 32078-32083 [Abstract] [Full Text]  
• Tiffany, H. L., Lavigne, M. C., Cui, Y.-H., Wang, J.-M., Leto, T. L., Gao, J.-L., Murphy, P. M. (2001). Amyloid-beta Induces Chemotaxis and Oxidant Stress by Acting at Formylpeptide Receptor 2, a G Protein-coupled Receptor Expressed in Phagocytes and Brain. J. Biol. Chem. 276: 23645-23652 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS