J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/05/1541/08 $2.00
Volume 185, Number 9, May 5, 1997 1541-1548

Role of Different T Cell Receptors in the Development of Pre-T Cells

By Jan Buer,^* Iannis Aifantis,^* James P. DiSanto, Hans Joerg Fehling,^§ and Harald von Boehmer^*

From the ^* Institut Necker, Institut National de la Santé et de la Recherche Médicale, 373, F-75730 Paris, Cedex 15, France;  Hôpital Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, 429, F-75743 Paris, France; and ^§ Basel Institute for Immunology, CH-4005 Basel, Switzerland

The development of pre-T cells with productive TCR- rearrangements can be mediated by each the pre-T cell receptor (pre-TCR), the TCR- as well as the TCR-, albeit by distinct mechanisms. Although the TCR- affects CD48 precursor cells irrespective of their rearrangement status by TCR- mechanisms not involving TCR- selection, both the preTCR and the TCR- select only cells with productive TCR- genes for expansion and maturation. The TCR- appears to be much less effective than the pre-TCR because of the paucity of TCR- proteins in TCR--positive precursors since an early expressed transgenic TCR- can largely substitute for the pre-TCR. Thus, the TCR- can assume a role not only in the rescue from programmed cell death of CD4⁺8⁺ but also of CD48 thymocytes. In evolution this double function of the TCR- may have been responsible for the maturation of T cells before the advent of the pre-TCR- chain.

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