CD30-mediated signaling promotes the development of human T helper type 2-like T cells

doi:10.1084/jem.182.6.1655

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CD30-mediated signaling promotes the development of human T helper type 2-like T cells

G Del Prete, M De Carli, MM D'Elios, KC Daniel, F Almerigogna, M Alderson, CA Smith, E Thomas and S Romagnani
Division of Clinical Immunology and Allergy, University of Florence, Italy.

We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti- CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag- specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.
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