Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes

doi:10.1084/jem.180.6.2309

This Article

	Full Text (PDF, 1461K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Reddy, M. A.
	Articles by Ostrowski, M. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Reddy, M. A.
	Articles by Ostrowski, M. C.


Social Bookmarking

	What's this?

ARTICLES

Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes

MA Reddy, BS Yang, X Yue, CJ Barnett, IL Ross, MJ Sweet, DA Hume and MC Ostrowski
Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710.

The receptor for macrophage colony stimulating factor (CSF-1), the c- fms gene product, is a key determinant in the differentiation of monocytic phagocytes. Dissection of the human and mouse c-fms proximal promoters revealed opposing roles for nuclear protooncogenes in the transcriptional regulation of this gene. On the one hand, c-ets-1, c- ets-2, and the macrophage-specific factor PU.1, but not the ets-factor PEA3, trans-activated the c-fms proximal promoter. On the other hand c- myb repressed proximal promoter activity in macrophages and blocked the action of c-ets-1 and c-ets-2. Basal c-fms promoter activity was almost undetectable in the M1 leukaemia line, which expressed high levels of c- myb, but was activated as cells differentiated in response to leukemia inhibitory factor and expressed c-fms mRNA. The repressor function of c- myb depended on the COOH-terminal domain of the protein. We propose that ets-factors are necessary for the tissue-restricted expression of c-fms and that c-myb acts to ensure correct temporal expression of c- fms during myeloid differentiation.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovski, S., Wong, P., Ernst, M. (2004). Imbalanced gp130-Dependent Signaling in Macrophages Alters Macrophage Colony-Stimulating Factor Responsiveness via Regulation of c-fms Expression. Mol. Cell. Biol. 24: 1453-1463 [Abstract] [Full Text]
You, X.-M., Mungrue, I. N., Kalair, W., Afroze, T., Ravi, B., Sadi, A. M., Gros, R., Husain, M. (2003). Conditional Expression of a Dominant-Negative c-Myb in Vascular Smooth Muscle Cells Inhibits Arterial Remodeling After Injury. Circ. Res. 92: 314-321 [Abstract] [Full Text]
Sasmono, R. T., Oceandy, D., Pollard, J. W., Tong, W., Pavli, P., Wainwright, B. J., Ostrowski, M. C., Himes, S. R., Hume, D. A. (2003). A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101: 1155-1163 [Abstract] [Full Text]
Hume, D. A., Ross, I. L., Himes, S. R., Sasmono, R. T., Wells, C. A., Ravasi, T. (2002). The mononuclear phagocyte system revisited. J. Leukoc. Biol. 72: 621-627 [Abstract] [Full Text]
Page, K., Li, J., Corbit, K. C., Rumilla, K. M., Soh, J.-W., Weinstein, I. B., Albanese, C., Pestell, R. G., Rosner, M. R., Hershenson, M. B. (2002). Regulation of Airway Smooth Muscle Cyclin D1 Transcription by Protein Kinase C-{delta}. Am. J. Respir. Cell Mol. Bio. 27: 204-213 [Abstract] [Full Text]
Henkel, G. W., McKercher, S. R., Maki, R. A. (2002). Identification of three genes up-regulated in PU.1 rescued monocytic precursor cells. Int Immunol 14: 723-732 [Abstract] [Full Text]
Tagoh, H., Himes, R., Clarke, D., Leenen, P. J.M., Riggs, A. D., Hume, D., Bonifer, C. (2002). Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells. Genes Dev. 16: 1721-1737 [Abstract] [Full Text]
Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., Behre, G. (2002). Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. Blood 100: 483-490 [Abstract] [Full Text]
Yamamoto, H., Kihara-Negishi, F., Yamada, T., Suzuki, M., Nakano, T., Oikawa, T. (2002). Interaction between the Hematopoietic Ets Transcription Factor Spi-B and the Coactivator CREB-binding Protein Associated with Negative Cross-talk with c-Myb. Cell Growth Differ. 13: 69-75 [Abstract] [Full Text]
Himes, S. R., Tagoh, H., Goonetilleke, N., Sasmono, T., Oceandy, D., Clark, R., Bonifer, C., Hume, D. A. (2001). A highly conserved c-fms gene intronic element controls macrophage-specific and regulated expression. J. Leukoc. Biol. 70: 812-820 [Abstract] [Full Text]
Afroze, T., Husain, M. (2000). c-Myb-binding Sites Mediate G1/S-associated Repression of the Plasma Membrane Ca2+-ATPase-1 Promoter. J. Biol. Chem. 275: 9062-9069 [Abstract] [Full Text]
Arai, F., Miyamoto, T., Ohneda, O., Inada, T., Sudo, T., Brasel, K., Miyata, T., Anderson, D. M., Suda, T. (1999). Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of c-Fms and Receptor Activator of Nuclear Factor {kappa}B (RANK) Receptors. JEM 190: 1741-1754 [Abstract] [Full Text]
Pan, Z., Hetherington, C. J., Zhang, D.-E. (1999). CCAAT/Enhancer-binding Protein Activates the CD14 Promoter and Mediates Transforming Growth Factor beta Signaling in Monocyte Development. J. Biol. Chem. 274: 23242-23248 [Abstract] [Full Text]
Lichanska, A. M., Browne, C. M., Henkel, G. W., Murphy, K. M., Ostrowski, M. C., McKercher, S. R., Maki, R. A., Hume, D. A. (1999). Differentiation of the Mononuclear Phagocyte System During Mouse Embryogenesis: The Role of Transcription Factor PU.1. Blood 94: 127-138 [Abstract] [Full Text]
Muller, C., Yang, R., Beck-von-Peccoz, L., Idos, G., Verbeek, W., Koeffler, H. P. (1999). Cloning of the cyclin A1 Genomic Structure and Characterization of the Promoter Region. GC BOXES ARE ESSENTIAL FOR CELL CYCLE-REGULATED TRANSCRIPTION OF THE cyclin A1 GENE. J. Biol. Chem. 274: 11220-11228 [Abstract] [Full Text]
Behre, G., Whitmarsh, A. J., Coghlan, M. P., Hoang, T., Carpenter, C. L., Zhang, D.-E., Davis, R. J., Tenen, D. G. (1999). c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor. J. Biol. Chem. 274: 4939-4946 [Abstract] [Full Text]
Rehli, M., Lichanska, A., Cassady, A. I., Ostrowski, M. C., Hume, D. A. (1999). TFEC Is a Macrophage-Restricted Member of the Microphthalmia-TFE Subfamily of Basic Helix-Loop-Helix Leucine Zipper Transcription Factors. J. Immunol. 162: 1559-1565 [Abstract] [Full Text]
Hahn, C. N., del Pilar Martin, M., Zhou, X.-Y., Mann, L. W., d'Azzo, A. (1998). Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin A under control of the colony-stimulating factor-1 receptor promoter. Proc. Natl. Acad. Sci. USA 95: 14880-14885 [Abstract] [Full Text]
Inoue, K., Sherr, C. J., Shapiro, L. H. (1998). Regulation of the CD13/Aminopeptidase N Gene by DMP1, a Transcription Factor Antagonized by D-Type Cyclins. J. Biol. Chem. 273: 29188-29194 [Abstract] [Full Text]
Ezashi, T., Ealy, A. D., Ostrowski, M. C., Roberts, R. M. (1998). Control of interferon-tau gene expression by Ets-2. Proc. Natl. Acad. Sci. USA 95: 7882-7887 [Abstract] [Full Text]
Hegde, S. P., Kumar, A., Kurschner, C., Shapiro, L. H. (1998). c-Maf Interacts with c-Myb To Regulate Transcription of an Early Myeloid Gene during Differentiation. Mol. Cell. Biol. 18: 2729-2737 [Abstract] [Full Text]
Yang, C., Shapiro, L. H., Rivera, M., Kumar, A., Brindle, P. K. (1998). A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions. Mol. Cell. Biol. 18: 2218-2229 [Abstract] [Full Text]
Ross, I. L., Yue, X., Ostrowski, M. C., Hume, D. A. (1998). Interaction between PU.1 and Another Ets Family Transcription Factor Promotes Macrophage-specific Basal Transcription Initiation. J. Biol. Chem. 273: 6662-6669 [Abstract] [Full Text]
Ratajczak, M. Z., Perrotti, D., Melotti, P., Powzaniuk, M., Calabretta, B., Onodera, K., Kregenow, D. A., Machalinski, B., Gewirtz, A. M. (1998). Myb and Ets Proteins Are Candidate Regulators of c-kit Expression in Human Hematopoietic Cells. Blood 91: 1934-1946 [Abstract] [Full Text]
Bellon, T., Perrotti, D., Calabretta, B. (1997). Granulocytic Differentiation of Normal Hematopoietic Precursor Cells Induced by Transcription Factor PU.1 Correlates With Negative Regulation of the c-myb Promoter. Blood 90: 1828-1839 [Abstract] [Full Text]
Tenen, D. G., Hromas, R., Licht, J. D., Zhang, D.-E. (1997). Transcription Factors, Normal Myeloid Development, and Leukemia. Blood 90: 489-519 [Full Text]
Nuchprayoon, I., Simkevich, C. P., Luo, M., Friedman, A. D., Rosmarin, A. G. (1997). GABP Cooperates With c-Myb and C/EBP to Activate the Neutrophil Elastase Promoter. Blood 89: 4546-4554 [Abstract] [Full Text]
Fears, S., Gavin, M., Zhang, D.-E., Hetherington, C., Ben-David, Y., Rowley, J. D., Nucifora, G. (1997). Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal�promoter. Proc. Natl. Acad. Sci. USA 94: 1949-1954 [Abstract] [Full Text]
Coffman, J., Kirchhamer, C., Harrington, M., Davidson, E. (1997). SpMyb functions as an intramodular repressor to regulate spatial expression of CyIIIa in sea urchin embryos. Development 124: 4717-4727 [Abstract]
Frampton, J, Ramqvist, T, Graf, T (1996). v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells.. Genes Dev. 10: 2720-2731 [Abstract]
Albanese, C., Johnson, J., Watanabe, G., Eklund, N., Vu, D., Arnold, A., Pestell, R. G. (1995). Transforming p21[IMAGE] Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions. J. Biol. Chem. 270: 23589-23597 [Abstract] [Full Text]
Shapiro, L. H., Shapiro, L. H. (1995). Myb and Ets Proteins Cooperate to Transactivate an Early Myeloid Gene. J. Biol. Chem. 270: 8763-8771 [Abstract] [Full Text]